PROCESS FOR MANUFACTURING ASPARTAME FROM A DIKETOPIPERAZINE AND NOVEL INTERMEDIATES AND DERIVATIVES THEREFOR
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(2008/06/13)
Process for preparing diketopiperazine derivatives
A diketopiperazine derivative is prepared by reacting chloroacetylaspartic acid with ammonia water, diesterifying the resulting glycyl-aspartic acid with an alkanol, and then cyclizing the diester in neutral or weakly basic water or in an alkanol-water solvent mixture.
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(2008/06/13)
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