- A simple, efficient and regioselective oxychlorination of aromatic compounds using ammonium chloride and oxone
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A simple, efficient, mild and regioselective method for oxychlorination of aromatic compounds is reported. The electrophilic substitution of chlorine generated in situ from NH4Cl as a chlorine source and oxone as an oxidant is reported for the first time.
- Narender,Mohan, K.V.V. Krishna,Srinivasu,Kulkarni,Raghavan
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p. 1335 - 1338
(2007/10/03)
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- Anthranilic acid derivatives as inhibitors of the cGMP-phosphodiesterase
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Compounds of formula (I) STR1where R 1 is hydrogen; R 2 is nitro, cyano or halo(lower)alkyl; R 3 is phenyl substituted with one or more substituents selected from halogen, cyano and lower alkoxy; A is a lower alkylene group; R 4 is a group CR 6 R 7 R 8 wherein R 6 and R 7 form, together with the carbon atom to which they are attached a cycloalkyl group optionally substituted with hydroxy, lower alkoxy or a lower alkanoylamino; and R 8 is hydrogen; its prodrug and a salt thereof.
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- Formation of Nonaromatic Products in the Chlorination of Simple Substituted Aromatic Ethers
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The neat chlorination of 4-chloroanisole produces 1,3,4,5,6-pentachloro-4-methoxycyclohexene in 35percent yield.Mono- and dichlorinated anisoles and a variety of simple substituted anisoles were chlorinated to determine the generality of nonaromatic product formation. 3,4-Dichloroanisole, 4-fluoroanisole, 4-bromoanisole, 4-methylanisole, and 4-chlorophenetole form similar products based on their spectral properties.These products are proposed to form by a cis-1,2-chlorine addition followed by rapid cis-1,4 chlorine addition.On the basis of the NMR data, a predominate configuration is proposed.
- Watson, William David
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p. 5270 - 5276
(2007/10/02)
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- Solvent and Acidity Effects in Chlorination of p-Methoxytoluene by Chloramine-T
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Kinetics of chlorination of p-methoxytoluene by chloramine-T (CAT) in aqueous acetic acid-perchloric acid medium is found to be zero order in and first order in .The acidity profile is curiously solvent dependent.The activation parameters in 50percent (v/v) aqueous acetic acid and at 60 deg C are ΔE(excit.) = 63.69 kJ mol-1, ΔH(excit.) = 60.94 kJ mol-1, log10A = 6.66 and ΔS(excit.) = -126.6 JK-1 mol-1.A plausible mechanism is suggested.
- Radhahrishnamurti, P. S.,Pati, Subas C.,Dev, B. R.
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p. 303 - 305
(2007/10/02)
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