- Rhodium-catalyzed dehydrogenative borylation of aliphatic terminal alkenes with pinacolborane
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Aliphatic terminal alkenes react with pinacolborane at ambient temperature to afford dehydrogenative borylation compounds as the major product when iPr-Foxap is used as the ligand with cationic rhodium(I) in the presence of norbornene, which acts as the s
- Morimoto, Masao,Miura, Tomoya,Murakami, Masahiro
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supporting information
p. 12659 - 12663
(2015/10/28)
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- SUBSTITUTED AROMATIC COMPOUNDS AND RELATED METHOD FOR THE TREATMENT OF FIBROSIS
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The present invention relates to compounds of: or a pharmaceutically acceptable salt thereof, wherein A is C5 alkyl, C6 alkyl, C5 alkenyl, C6 alkenyl, C(0)-(CH2)n-CH3 or CH(OH)-(CH2)n-CH3 wherein n is 3 or 4; R1 is H, F or OH; R2 is C5 alkyl, C6 alkyl, C5 alkenyl, C6 alkenyl, C(0)-(CH2)n-CH3 or CH(OH)-(CH2)n-CH3 wherein n is 3 or 4; R3 is H, F, OH or CH2Ph; R4 is H, F or OH; Q is 1 ) (CH2)mC(0)OH wherein m is 1 or 2, 2) CH(CH3)C(0)OH, 3) C(CH3)2C(0)OH, 4) CH(F)-C(0)OH, 5) CF2-C(0)OH, or 6) C(0)-C(0)OH; and compositions comprising the same and the method using the same for the prevention or treatment of various fibrotic diseases and conditions in subjects, including pulmonary fibrosis, liver fibrosis, skin fibrosis, renal fibrosis, pancreas fibrosis, systemic sclerosis, cardiac fibrosis or macular degeneration.
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Page/Page column 32; 33
(2014/09/29)
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- Catalytic, regiospecific end-functionalization of alkanes: Rhenium-catalyzed borylation under photochemical conditions
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Approaching a Holy Grail? A regioselective functionalization of alkanes occurs with commercially available rhenium catalysts and borane reagents under photochemical conditions [Eq.(1)]. Mechanistic studies indicate that the regioselectivity results from a direct thermal reaction of a photochemically generated 16- electron boryl complex with alkane.
- Chen, Huiyuan,Hartwig, John F.
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p. 3391 - 3393
(2007/10/03)
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