Titanium-catalyzed stereoselective synthesis of spirooxindole oxazolines
A regio-and stereoselective cyclization between isatins and 5-methoxyoxazoles has been developed using catalytic titanium (IV) chloride (10 or 20 mol %) to afford spiro[3,3'-oxindoleoxazolines] in excellent yield (up to 99%) and diastereoselectivity (dr >
Badillo, Joseph J.,Arevalo, Gary E.,Fettinger, James C.,Franz, Annaliese K.
p. 418 - 421
(2011/04/15)
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