- Inhibition by active site directed covalent modification of human glyoxalase i
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The glyoxalase pathway is responsible for conversion of cytotoxic methylglyoxal (MG) to d-lactate. MG toxicity arises from its ability to form advanced glycation end products (AGEs) on proteins, lipids and DNA. Studies have shown that inhibitors of glyoxa
- Holewinski, Ronald J.,Creighton, Donald J.
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- Studies on synthesis, characterization, micellar features, and solubilization of four novel cationic gemini surfactants
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Four novel cationic gemini surfactants with the same hydrocarbon chain lengths but different spacers have been investigated in this article. After these cationic gemini surfactants have been synthesized, their structures have been characterized by appropr
- Bilgen, Sel?uk,Sarikaya, Ikbal,ünver, Yasemin,Akba?, Halide
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p. 1522 - 1532
(2021/04/02)
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- Synthesizing method of imidazole type Gemini surfactant
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The invention discloses a synthesizing method of imidazole type Gemini surfactant. The synthesizing method is characterized in that N-alkyl imidazole is synthesized by using imidazole and alkyl bromide, reaction temperature is 25 DEG C, reaction time is 8 hours, and the yield is about 70%; bromoacetic acid 1, 4-butanediyl ester is synthesized by using bromoacetic acid and dihydric alcohol, reaction temperature is 125 DEG C, and reaction time is 24 hours; the final product is synthesized by using the N-alkyl imidazole and the bromoacetic acid 1, 4-butanediyl ester, reaction temperature is 85 DEG C, reaction time is 36 hours, and yield is about 85%. The synthesizing path is shown as follows, wherein n=2, 4, 6.
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Paragraph 0018
(2016/10/09)
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