- 7-SUBSTITUTED 1-PYRIDYL-NAPHTHYRIDINE-3-CARBOXYLIC ACID AMIDES AND USE THEREOF
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The present application relates to novel 7-substituted 1-pyridylnaphthyridine-3-carboxamides, to processes for their preparation, to their use, alone or in combinations, for the treatment and/or prevention of diseases, and to their use for the production
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Paragraph 0479-0482
(2019/08/20)
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- POSITIVE ALLOSTERIC MODULATORS OF MUSCARINIC M2 RECEPTOR
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The present application relates to positive allosteric modulators of the muscarinic M2 receptor, especially to novel 7-substituted 1-arylnaphthyridine-3-carboxamides, to processes for preparation thereof, to the use thereof, alone or in combinations, for treatment and/or prevention of diseases, and to the use thereof for production of medicaments for treatment and/or prevention of diseases, in particular for treatment and/or prevention of cardiovascular disorders and/or renal disorders.
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Paragraph 1362-1365
(2018/11/21)
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- Ru-catalyzed asymmetric hydrogenation of γ-heteroatom substituted β-keto esters
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A series of enantiomerically pure γ-heteroatom substituted β-hydroxy esters were synthesized with high enantioselectivities (up to 99.1% ee) by hydrogenation of γ-heteroatom substituted β-keto esters in the presence of Ru-(S)-SunPhos catalyst. These asymmetric hydrogenations provide key building blocks for a variety of naturally occurring and biologically active compounds.
- Fan, Weizheng,Li, Wanfang,Ma, Xin,Tao, Xiaoming,Li, Xiaoming,Yao, Ying,Xie, Xiaomin,Zhang, Zhaoguo
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experimental part
p. 9444 - 9451
(2012/01/13)
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- PYRAZOLE COMPOUNDS AND USE THEREOF
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The pyrazole compound of the present invention is represented by the following general formula (I). The pyrazole compound of the present invention or a salt thereof or a solvate thereof potently inhibits liver glycogen phosphorylase, and, therefore, is useful as a therapeutic or prophylactic agent for diabetes. wherein each symbol denotes as described in the specifications.
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Page/Page column 39-40
(2009/05/29)
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- 1,3-Dipolar cycloaddition route to nitrogen heterocyclic triones
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1,3-Dipolar cycloaddition of nitrile oxides, formed in situ by dehydration of primary nitro compounds, with pyrrolidine enamines of protected γ- or δ-amino-β-keto esters affords isoxazole-4-carboxylates; these undergo lactam formation and N-O bond cleavage to afford 3-acyltetramic acids and 3-acyl-4-hydroxypyridin-2-ones.
- Jones, Raymond C. F.,Bhalay, Gurdip,Carter, Paul A.,Duller, Kathryn A. M.,Dunn, Stephen H.
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p. 765 - 776
(2007/10/03)
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- Process for preparing optically active 4-hydroxy-2-pyrrolidone
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A process for preparing optically active 4-hydroxy-2-pyrrolidone comprising asymmetrically hydrogenating an N-substituted-4-amino-3-oxobutanoic ester represented by formula (I): STR1 wherein R1 represents a benzyloxycarbonyl group, the benzene
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