- Synthesis method of 2-(2,4,6-trichlorophenoxy)ethyl propylamine
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The invention discloses a synthesis method of 2-(2,4,6-trichlorophenoxy)ethyl propylamine. The method comprises the following steps: reacting 2,4,6-trichlorophenol with cycloethylamine under the catalysis of boron trifluoride diethyl ether, and conducting salifying with hydrochloric acid to obtain a compound A; and under the catalysis of cesium hydroxide monohydrate, reacting the compound A with 1-bromopropane by taking sodium carbonate as an acid-binding agent to obtain 2-(2,4,6-trichlorophenoxy)ethyl propylamine. The method is simple in operation steps, the used reaction raw materials are cheap and easy to obtain, total molar yield is 94.18%, the purity of the produced 2-(2,4,6-trichlorophenoxy)ethyl propylamine is 98.0% or above, product quality is good, and the method is suitable for industrial production.
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Paragraph 0016; 0032-0034; 0035-0036
(2020/09/09)
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- Safe and reliable prochloraz preparation method
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The invention discloses a safe and reliable prochloraz preparation method. The safe and reliable prochloraz preparation method comprises following steps: S1, etherification reaction, wherein 2, 4, 6-trichlorophenol, a liquid alkali, and dichloroethane are subjected to sealing heating reaction so as o obtain a S1 etherification intermediate; S2, amination reaction, wherein propylanmine is added, heating reaction is carried out, distillation recycling of propylanmine is carried out, and extraction is carried out so as to obtain a S2 secondary amine intermediate solution; S3, esterification reaction, wherein an acid binding agent A, and a halogenated formate are added, room temperature reaction is carried out for 1 to 3h, and filtering is carried out so as to obtain a S3 esterification intermediate solution; and S4, carbonylation condensation reaction, wherein catalyst B and imidazole are added, reflux reaction is carried out, and washing, extraction, and distillation are carried out so as to obtain prochloraz finished product. According to the safe and reliable prochloraz preparation method, the halogenated formate is adopted to replace a phosgene similar agent as a carbonylation condensation reagent, and sealing, waterless, and rectification reflux reaction conditions are adopted, so that continuous production is realized; the prochloraz total yield is high; no phosgene leakagesafety hidden trouble is caused; and the safe and reliable prochloraz preparation method is worthy of popularization.
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Paragraph 0053; 0055; 0058; 0060; 0062; 0064
(2019/10/01)
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- Substituted heteroaralkyl, heteroaralkenyl or halomethyl fungicides
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Compounds of the formula: STR1 wherein R is phenyl or phenyl substituted with 1 to 4 of the same or different substituents selected from fluoro, chloro, bromo, iodo, lower alkyl and trihalomethyl; R1 is lower alkyl; Y is lower alkenyl substituted with a 5- or 6-member heterocyclic ring containing 1 to 3 nitrogen atoms and the remainder of the ring atoms carbon atoms, or --CH2 W wherein W is fluoro, chloro, bromo, iodo, or a 5- to 6-member heterocyclic ring containing 1 to 3 nitrogen atoms and the remainder of the ring atoms carbon atoms; and X and Z are independently sulfur or oxygen; are effective fungicides.
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- Fungicidal (trihalophenoxy or trihalophenthio) alkylaminoalkyl pyridines and pyrroles
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Compounds of the Formula: STR1 wherein X is sulfur or oxygen; R is phenyl or phenyl substituted with 1 to 3 substituents independently selected from fluoro, chloro, bromo, iodo, lower alkyl or trihalomethyl; R1 is lower alkyl or lower alkoxyalkyl; and R2 is 5- or 6-member heterocyclic ring having 1 to 3 ring nitrogens and the remainder of the ring atoms carbon atoms, optionally substituted with 1 to 2 independent lower alkyl groups, provided that a nitrogen of the 5- or 6-member heterocyclic ring is not bonded to the adjacent --CH2 -- group; or the group --CH2 --R3 wherein R3 is a 5- or 6-member heterocyclic ring having 1 to 3 ring nitrogens and the remainder of the ring atoms carbon atoms, are fungicidal.
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- Certain N,N-di-substituted-pyridine carboxamides, fungicidal compositions and fungicidal method of use
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The substituted heteroaryl compounds of this invention are good fungicides. In particular, they possess especially good activity against Bean Powdery Mildew.
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