Synthesis and biological evaluation of a new class of multi-target heterocycle piperazine derivatives as potential antipsychotics
In this study, we designed and synthesized a novel series of multi-receptor ligands as polypharmacological antipsychotic agents by using a multi-receptor affinity strategy. Among them,3wcombines a multi-receptor mechanism with high mixed affinities for D
Compounds and methods for treatment of amyloid-B-peptide related disorders
The present invention relates to compounds, preparation and uses thereof, particularly in the pharmaceutical industry. The present invention discloses novel compounds of the following formula (I) more particularly useful for the treatment of Alzheimer's d
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Page/Page column 20
(2008/06/13)
Alkyl- and alkoxy-substituted lamtidine analogues: Synthesis and H2-antagonistic activity. 38th Communication: H2-antihistaminics
In studies on the structure-activity relationships of histamine H2-receptor antagonists, lamtidine analogous derivatives of ortho-, meta- and para-substituted piperidinomethylphenoxypropylamines bearing an additional substituent on the aromatic
Bonjean,Schunack
p. 501 - 507
(2007/10/02)
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