3,4-Diamino-1,2,5-thiadiazole as potent and selective CXCR2 antagonists
A series of potent and selective 3,4-diamino-1,2,5-thiadiazoles were prepared and found to show excellent binding affinities towards CXCR2 receptor.
Biju, Purakkattle,Taveras, Arthur G.,Yu, Younong,Zheng, Junying,Hipkin, R. William,Fossetta, James,Fan, Xuedong,Fine, Jay,Lundell, Daniel
scheme or table
p. 1434 - 1437
(2009/10/15)
3,4-Diamino-2,5-thiadiazole-1-oxides as potent CXCR2/CXCR1 antagonists
A series of novel and potent 3,4-diamino-2,5-thiadiazole-1-oxides were prepared and found to show excellent binding affinities for CXCR2 and CXCR1 receptors and excellent inhibitory activity of Gro-α and IL-8 mediated in vitro hPMN MPO release of CXCR2 an
Biju, Purakkattle,Taveras, Arthur,Yu, Younong,Zheng, Junying,Chao, Jianhua,Rindgen, Diane,Jakway, James,Hipkin, R. William,Fossetta, James,Fan, Xuedong,Fine, Jay,Qiu, Hongchen,Merritt, J. Robert,Baldwin, John J.
p. 228 - 231
(2008/09/17)
A new synthesis of 3,4-disubstituted 1,2,5-thiadiazoles
A simple and convenient reduction of 3,4-diamino derivatives of 2,5-thiadiazole-1-oxide to the corresponding 1,2,5-thiadiazoles has been accomplished using Ph3P and CCl4 in dichloromethane.
Biju, Purakkattle,Yu, Younong
p. 5279 - 5282
(2008/02/08)
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