- PROCESS FOR PRODUCING SUBSTITUTED AMINO ALCOHOLS
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The present invention relates to a process for producing a compound of the formula (I) comprising at least the process step: a) reacting a compound of the formula (II) with hydrogen and water in the presence of at least one homogeneous transition metal catalyst TMC 1.
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Page/Page column 30; 31; 34-37
(2020/06/01)
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- Ruthenium-Catalyzed Deaminative Hydrogenation of Amino Nitriles: Direct Access to 1,2-Amino Alcohols
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A new approach for the efficient and highly selective synthesis of 1,2-amino alcohols by direct reductive hydrolysis of N-formyl-protected α-amino nitriles is reported. The commercially available RuHCl(CO)(PPh3)3 complex was found to be a suitable catalyst for this operationally simple protocol, in which no stoichiometric amounts of undesired metal waste are generated. The deaminative hydrogenation is performed at 55 bar of H2, using a 6:1 mixture of 1,4-dioxane/water as solvent. In addition, hydroxymethyl alcohols were prepared from cyanoketones under very similar conditions.
- Calleja, Pilar,Ernst, Martin,Hashmi, A. Stephen K.,Schaub, Thomas
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supporting information
p. 9498 - 9503
(2019/04/30)
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- Microwave-assisted synthesis of N-sec- and N-tert-alkylated indoles
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A synthesis of N-substituted indoles by means of an epoxide-opening, nucleophilic aromatic substitution, and dehydration sequence is reported, which is capable of generating even N-tert alkyl substituted derivatives. Georg Thieme Verlag Stuttgart.
- Schirok, Hartmut
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p. 1404 - 1414
(2008/12/21)
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