- Backbone-Modified C2-Symmetrical Chiral Bisphosphine TMS-QuinoxP*: Asymmetric Borylation of Racemic Allyl Electrophiles
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A new C2-symmetrical P-chirogenic bisphosphine ligand with silyl substituents on the ligand backbone, (R,R)-5,8-TMS-QuinoxP*, has been developed. This ligand showed higher reactivity and enantioselectivity for the direct enantioconvergent borylation of cy
- Imamoto, Tsuneo,Ito, Hajime,Iwamoto, Hiroaki,Ozawa, Yu,Takenouchi, Yuta
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supporting information
p. 6413 - 6422
(2021/05/31)
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- Cyclotriol derivative and production method and application thereof
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The invention discloses a cyclotriol derivative and a production method and application thereof. The cyclotriol derivative is of a structure as shown in a general formula I, wherein R1, R2 and R3 areOH or AcNH; R1=OH, and R2=R3=AcNH or R2=OH, and R1=R3=AcNH or R3=OH, and R1=R2=AcNH; * stands for R configuration or S configuration; and Ac stands for caffeoyl CAc or derivatives caffesulfonyl SAc and caffe(mono-methyl ester)phosphonyl PAc of the caffeoyl CAc. According to the production method of the cyclotriol derivative, conditions are mild, automatic and industrial production are easy to achieve, operation is simple, convenient and safe, and the obtained cyclotriol derivative can act on anti-respiratory syncytial virus F protein, has high anti-RSV activity, low cell toxicity and high stability, can be used for producing medicines for treating virus infection, and is especially used for producing medicines for treating respiratory syncytial virus infection.
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Paragraph 0138; 0146; 0149; 0150
(2019/09/13)
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- COMPOUNDS AND COMPOSITIONS USEFUL FOR TREATING DISORDERS RELATED TO NTRK
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This invention relates to inhibitors of NTRK that are active against wild-type NTRK and its resistant mutants.
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Page/Page column 53; 54
(2017/03/14)
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- The activity of covalently immobilized Grubbs-Hoveyda type catalyst is highly dependent on the nature of the support material
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A Hoveyda-type catalyst for olefin metathesis was synthesized and covalently attached via an amide bond to four different solid supports. One of these supports was a home-made hybrid silica support, where an ultra-thin copolymer of poly(styrene) and poly(acrylamide) was grafted on. The three other supports were commercially available, namely HypoGel 400, PEGA and Trisoperl. It was demonstrated that the catalysts were active in ring closing metathesis (RCM) reactions as well as in cross metathesis (CM) and ring opening metathesis (ROM) reactions, but the activity of the catalyst was highly dependent on the nature of the support.
- Michalek, Florian,M?dge, Daniel,Rühe, Jürgen,Bannwarth, Willi
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p. 5172 - 5180
(2007/10/03)
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- Application of a Grubbs-Hoveyda metathesis catalyst noncovalently immobilized by fluorous-fluorous interactions
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A Grubbs-Hoveyda metathesis catalyst bearing a tris(perfluoroalkyl)silyl tag for efficient noncovalent attachment to fluorous silica gel (FSG) was synthesized and employed in ring-closing metathesis (RCM) reactions in CH 2Cl2. After
- Michalek, Florian,Bannwarth, Willi
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p. 1030 - 1037
(2007/10/03)
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- Catalysts on functionalized polymer chips (PC) as recyclable entities
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We describe surface-modified sintered polyethylene sheets as a suitable carrier system for various catalysts. The material shows high rigidity and no swelling properties and allows for easy removal and reuse of the supported catalysts. The application was demonstrated for Pd-, Rh-, and Ru-catalysts in Suzuki couplings, hydroformylation, and olefin metathesis, respectively. Georg Thieme Verlag Stuttgart.
- Koc, Fikret,Michalek, Florian,Rumi, Luigi,Bannwarth, Willi,Haag, Rainer
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p. 3362 - 3372
(2007/10/03)
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- A tandem ring-closing metathesis cleavable linker system for solid-phase oligosaccharide synthesis
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A novel triene linker system, that can be cleaved by a tandem ring-closing metathesis (RCM) reaction, is presented. The tandem RCM cleavage, that regenerates the active ruthenium catalyst without the need of additives like ethylene, proceeded very clean and fast to liberate cyclopent-2-enyl mannosides from the solid support. A cyclopent-2-enyl mannoside was isomerized to the corresponding vinyl ether glycoside, which could be readily deprotected by iodine-mediated hydrolysis.
- Timmer, Mattie S. M.,Codée, Jeroen D. C.,Overkleeft, Herman S.,Van Boom, Jacques H.,Van Der Marel, Gijsbert A.
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p. 2155 - 2158
(2007/10/03)
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- Regiochemical Control of the Ring-Opening of Epoxides by Means of Chelating Processes, 13. Synthesis and Ring-Opening Reactions of the Diastereoisomeric cis- and trans-Epoxides Derived from 3-(Benzyloxy)cyclopentene and 2-(Benzyloxy)-2,5-dihydrofuran
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The regiochemical outcome of the ring-opening of epoxides bearing remote polar functionalities has been established in the case of carbocyclic (1 and 2) and the corresponding furanosidic (3 and 4) title epoxides. Under standard conditions, the regioisomeric C-1 products are the sole (from trans epoxides 2 and 4) or predominant (from cis epoxides 1 and 3) ring-opening products. However, under chelating conditions, and only in the case of the cis epoxides 1 and 3, a consistent increase in C-2 selectivity is unexpectedly observed. - Keywords: Epoxides; Regioselectivity; Nucleophilic additions; Synthetic methods
- Crotti, Paolo,Bussolo, Valeria Di,Favero, Lucilla,Macchia, Franco,Pineschi, Mauro
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p. 1675 - 1686
(2007/10/03)
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- COHALOGENATION DES OLEFINES : APPLICATION A LA SYNTHESE D'ALCOOLS ALLYLIQUES
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Alkenes 1 a-f are converted in three steps into the ally alcohols 4 a-f ; the cohalogenation of alkenes by NBS in alcohols constitutes the first step of this synthesis.
- Rodriguez, J.,Dulcere, J-P,Bertrand, M.
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p. 527 - 528
(2007/10/02)
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