- A chemoselective deoxygenation of N-oxides by sodium borohydride-Raney nickel in water
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A simple and convenient protocol for deoxygenation of aliphatic and aromatic N-oxides to the corresponding amines in good to excellent yield using sodium borohydride-Raney nickel in water is reported. Other functional moieties such as alkenes, halides, ethers, and amides are unaffected under the present reaction condition.
- Gowda, Narendra B.,Rao, Gopal Krishna,Ramakrishna, Ramesha A.
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supporting information; experimental part
p. 5690 - 5693
(2010/11/05)
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- Metabolism of imipramine by microorganisms
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The microbial metabolism of imipramine was studied using selected fungal organisms. The major microbial metabolites were isolated, and their structures were established by spectroscopic analyses (particularly 13C-NMR) and by comparison with authentic samples. The microbial metabolites identified included 2-hydroxyimipramine, 10-hydroxyimipramine, iminodibenzyl, imipramine-N-oxide, and desipramine; these metabolites also have been found in mammalian metabolism studies.
- Hufford,Capiton,Clark,Baker
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p. 151 - 155
(2007/10/02)
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