Aralkyl-ketone piperazine derivatives and their uses as new antalgic or ataractic agent
Arylalkyl ketone piperazine derivatives of the formula: and pharmaceutical compositions comprising the same. Also dislcosed are methods for using the compounds as analgesic and sedative agents. The compounds of the present invention have good analgesic and sedative activities but few side effects.
-
Page/Page column 8
(2008/06/13)
COMPOUNDS INTERACTING WITH THE NEUROEXCITATORY AMINO ACIDS: SYNTHESIS OF 2-(4-ARALKYLPIPERAZINE-1-YL)-1-ARYLETHANOLS
Amino ketones Ia - If and III were synthesized.Their reduction gave corresponding alcohols IIa - IIf, IVa and IVb.These were evaluated by methods of biochemical and behavioural pharmacology.