A β-hairpin peptide with pH-controlled affinity for tumor cells
Considering that the pH in the tumor microenvironment is dysregulated, we designed a β-hairpin peptide (SSRFEWEFESSDPRGDPSSRFEWEFESS). The configuration of the peptide switched from a flexible linear to a rigid loop structure under weakly acidic conditions. The peptide internalized by tumor cells increased significantly under weakly acidic conditions.
Highly sensitive detection of cobalt through fluorescence changes in β-cyclodextrin-bimane complexes
A supramolecular complex ofsyn-(methyl,methyl)bimane (1) and β-cyclodextrin demonstrates a sensitive (limit of detection = 0.60 nM) and selective fluorescence turn-off response in the presence of cobalt in aqueous media, with calibration curves enabling quantitation in solution and using filter papers on which bimane and cyclodextrin were adsorbed.1H NMR spectroscopy provides insight into interactions underlying the sensor performance.
Dihalogen and Solvent-Free Preparation of syn- Bimane
Fluorescent bimanes are low molecular weight and low toxicity molecules with applications ranging from biology to LASER dyes. The widespread use of these molecular probes has presumably been stalled by the hazards involved in their current synthetic preparation which involve handling of dangerous halogens like chlorine (gas) and bromine (liq.). The accessibility achieved by the simple and safe dihalogen and solvent-free methodologies described here open the floodgates to additional future practical applications of bimanes.
Neogi, Ishita,Das, Partha J.,Grynszpan, Flavio
p. 1043 - 1046
(2018/03/28)
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