- Vinylene carbonate: Beyond the ethyne surrogate in rhodium-catalyzed annulation with amidines toward 4-methylquinazolines
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In this paper, we developed a rhodium-catalyzed annulation of vinylene carbonate with amidines, leading to 4-methylquinazolines with moderate to excellent yields. This procedure proceeded by sequentialortho-acylation and annulation, where vinylene carbonate served as the acetylation reagent rather than the ethyne surrogate.
- Wang, Chang,Fan, Xiaodong,Chen, Fan,Qian, Peng-Cheng,Cheng, Jiang
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supporting information
p. 3929 - 3932
(2021/04/26)
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- Quinazoline compounds and preparation method thereof
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The invention discloses quinazoline compounds which have a specific structural formula as shown in the description, wherein R1 is aryl, substituted aryl or alkyl; R2 is fluorine, chlorine or methyl; R3 is aryl, substituted aryl or alkyl. By taking amino a
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Paragraph 0044; 0045
(2016/10/10)
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- Heterogeneous Palladium-Catalyzed Hydrogen-Transfer Cyclization of Nitroacetophenones with Benzylamines: Access to C?N Bonds
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The first Pd/C-catalyzed oxidative C(sp3)?H bond amination of o-nitroacetophenones with benzylamines or amino acids proceeding through C?N bond cleavage followed by C?N bond formation by a hydrogen-transfer strategy was developed. These transformations proceeded smoothly in water to afford the desired quinazolines in moderate to good yields. This protocol has a broad substrate scope and good tolerance of air, offers excellent recyclability of the catalyst, and does not need any additional oxidant, ligand, or base; the combination of all of these factors give a new and practical avenue for multiple C?N bond formation. Moreover, a hot filtration experiment indicated that heterogeneous palladium nanoparticles during the reaction are the active species.
- Tang, Lin,Wang, Pengfei,Fan, Yang,Yang, Xingkun,Wan, Changfeng,Zha, Zhenggen
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p. 3565 - 3569
(2016/12/14)
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