Peptide Decomposition in the Neutral pH Region via the Formation of Diketopiperazines
In the neutral pH region, the decomposition of the tripeptides Leu-Gly-Gly and Gly-Leu-Gly at 130 deg C and the hexapeptide Phe-Gly-Leu-Gly-Val-Gly at 100 deg C has been found to involve the formation of diketopiperazines from the N-terminal position of the peptides.
Steinberg, Spencer M.,Bada, Jeffrey L.
p. 2295 - 2298
(2007/10/02)
Decarbobenzoxylation of amino acids and derivatives with water-free trifluoroacetic acid.