- Ochraceopetalin, a mixed-biogenetic salt of polyketide and amino acid origins from a marine-derived aspergillus ochraceopetaliformis fungus
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Ochraceopetalin (1), a mixed-biogenetic salt compound and its component 2 were isolated from the culture broths of a marine-derived fungus, Aspergillus ochraceopetaliformis. Based on combined spectroscopic and chemical analyses, the structure of 1 was determined to be a sulfonated diphenylether-aminol-amino acid ester guanidinium salt of an unprecedented structural class, while 2 was determined to be the corresponding sulfonated diphenylether. Ochraceopetaguanidine (3), the other guanidine-bearing aminol amino acid ester component, was also prepared and structurally elucidated. Compound 1 exhibited significant cytotoxicity against K562 and A549 cells.
- Park, Sung Chul,Lee, Jung-Ho,Hwang, Ji-Yeon,Kwon, Oh-Seok,Liao, Lijuan,Oh, Dong-Chan,Oh, Ki-Bong,Shin, Jongheon
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- Tolyprolinol, a new dipeptide from Tolypocladium sp. FKI-7981
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A new dipeptide, named tolyprolinol, was isolated from the static culture of a fungus, Tolypocladium sp. FKI-7981. The structure of tolyprolinol was elucidated as N-acetyl-l-phenylalanyl-l-prolinol. It showed moderate antimalarial activity but did not show cytotoxicity or any other antimicrobial property.
- Fukasawa, Wataru,Mori, Natsuki,Iwatsuki, Masato,Hokari, Rei,Ishiyama, Aki,Nakajima, Moe,Ouchi, Takahito,Nonaka, Kenichi,Kojima, Hiroki,Matsuo, Hirotaka,ōmura, Satoshi,Shiomi, Kazuro
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p. 682 - 684
(2018/03/26)
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- OPTISCH AKTIVE β(AMINO)ETHYL-PHOSPHONSAEUREESTER, β(AMINO)ETHYL-PHENYLPHOSPHINSAEUREESTER, β(AMINO)ETHYL-DIPHENYLPHOSPHINOXYDE UND β(AMINO)ETHYL-DIPHENYLPHOSPHINE
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The title compounds are prepared by Michael-type additions of primary and secondary amines to P(O)-activated vinylsystems resp. diphenyl-vinylphosphine.
- Maerkl, G.,Merkl, B.
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p. 4459 - 4462
(2007/10/02)
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