- Optical Resolution by Preferential Crystallization of 1,1,3,3-Tetramethylbutylammonium Salt of N-Formyl-DL-α-phenylglycine
-
Infrared spectrum, solubility, and ternary phase diagram of solubility indicated that 1,1,3,3-tetramethylbutylammonium salt (DL-TMB salt) of N-formyl-DL-α-phenylglycine is a conglomerate.In order to resolve DL-TMB salt efficiently, crystallization of D- and L-TMB salts was examined by free energy of critical nucleation in supersaturated solutions.Successive preferential crystallization of DL-TMB salt was experimented at 10 deg C for racemic solution in ethanol with the degree of supersaturation of 130percent, and D- and L-α-phenylglycine with 100percent optical purity were obtained from pure D- and L-TMB salts.
- Shiraiwa, Tadashi,Miyazaki, Hideya,Imai, Tomoki,Sunami, Michio,Kurokawa, Hidemoto
-
p. 661 - 666
(2007/10/02)
-
- STEREOSELECTIVE REDUCTION OF RACEMIC N-HYDROXYAMINO ACIDS BY OPTICALLY ACTIVE THIOLS-IRON(II)
-
Kinetic resolution of racemic N-hydroxyamino acids by the reduction with optically active thiols and a catalytic amount of ferrous ion gave optically active amino acids presumably through enantiodifferentiating coordination of substrates to thiol-Fe(II) complexes.
- Nambu, Yoko,Endo, Takeshi
-
p. 999 - 1002
(2007/10/02)
-