- Pharmaceutically efficacious pteridine derivatives
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A pharmaceutically efficacious pteridine compound of formula I: STR1 wherein A denote a bridging hydrocarbon group containing 1 to 8 carbon atoms and containing a STR2 group directly bonded to the phenyl group and one of the methylene radicals of the bridging A group is optionally replaced by --O--; R1 is hydrogen, a cycloalkyl group with up to 7 carbon ring atoms, or an alkyl group having 1 to 6 carbon atoms, benzyl, or aryl; R2 is hydrogen or an alkyl group having 1 to 6 carbon atoms, or wherein R1 and R2 together form a five- or six-membered heterocyclic group which optionally contains additional hetero atoms selected from the group consisting of nitrogen, oxygen, and sulfur; R3 is hydrogen or an alkyl group having 1 to 3 carbon atoms; R3 ' is hydrogen, an optionally substituted alkyl group having 1 to 3 carbon atoms, carboxyl, hydroxyl or R3 and R3 ' together with the carbon atom to which they are attached form a cycloalkyl group and the pharmaceutically acceptable acid addition salts thereof.
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- Cleavage of Phenolbenzyl Ethers Catalysed by Heavy Metals
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MnCl2, CuCl and CoCl2 catalyse the cleavage of 3-propyl chloride (2) by gaseous HCl with subsequent formation of phenol and 3-propyl chloride (1).NiCl2 and CrCl3 are not useful as catalysts.Two phenol deriv
- Oelschlaeger, Herbert,Linde, Hermann,Goetze, Gudrun,Iglesias-Meier, Julia
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p. 897 - 905
(2007/10/02)
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