Stereoselective biocatalytic synthesis of (S)-2-hydroxy-2-methylbutyric acid via substrate engineering by using "thio-disguised" precursors and oxynitrilase catalysis
3-Tetrahydrothiophenone (4) and 4-phenylthiobutan-2-one (7) were used as masked 2-butanone equivalents to give the corresponding cyanohydrins 5 (79% yield, 91% ee) and 8 (95% yield, 96% ee) in an enzymatic cyanohydrin reaction applying the hydroxynitrile
Fechter, Martin H.,Gruber, Karl,Avi, Manuela,Skranc, Wolfgang,Schuster, Christian,Poechlauer, Peter,Klepp, Kurt O.,Griengl, Herfried
p. 3369 - 3376
(2008/01/06)
More Articles about upstream products of 691890-02-5