- Building blocks for oligomeric siloxanes –selective chlorination of hydrido-siloxanes
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A new method was developed to achieve highly selective monochlorination of α,ω-dihydridosiloxanes, ((H)Me2SiO-(SiMe2O)n-SiMe2(H), n = 0–2; (H)R2Si–O-SiR2(H); R = Me, iPr, Ph; 3,5-dihydridooctamethyltetrasiloxane, Me3SiO-(Si(H)MeO)2–SiMe3) with trichloroisocyanuric acid (TCCA). The dependence of the selectivity of the monochlorination on the siloxane chain length is also discussed.
- Hafner, Thomas,Torvisco, Ana,Uhlig, Frank
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supporting information
p. 1 - 4
(2018/09/11)
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- The PdCl2/R3SiH system for the silylation of nucleosides
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Convenient syntheses of TIPDS-Cl2 and TBDMS-Br from the corresponding hydrides were obtained by using catalytic PdCl2 and CCl4 or CH2Br2, respectively. These systems can be successfully applied in tandem procedures for improved silylation of nucleosides.
- Ferreri,Costantino,Romeo,Chatgilialoglu
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p. 1197 - 1200
(2007/10/03)
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- Preparation of 1,1,3,3-tetraisopropyl-1,3-dichlorodisiloxane and triisopropylchlorosilane
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A facile, hydrochloric acid-free chlorination of silanes was developed. This allows for the elimination of siloxane bond cleavage and chlorination of carbon-hydrogen bonds during the chlorination of the Si-H bond.
- Chawla, Ram,Larson, Gerald L.
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p. 3499 - 3501
(2007/10/03)
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- Chiral Hydroxymethyl Groups: 1H NMR Assignments of the Prochiral C-5'Protons of 2'-Deoxyribonucleosides
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2'-Deoxyadenosine, 2'-deoxycytidine, 2'-deoxyguanosine and 2'-deoxyuridine were prepared with stereoselective deuteration at C-5' and used to assign the prochiral C-5' protons in 300 MHz 1H NMR spectra obtained in 2H2O.In all cases, the more shielded C-5'proton was found to be the pro-R proton.From these assignments, C-4'-C-5' rotamer populations were determined using three previously published methods based on the spin couplings, 3J(H-4',H-5'R) and 3J(H-4',H-5'S), and the errors associated with these methods were assessed.The effects of base structure, furanose and N-glycoside bond conformation on the relative populations of hydroxymethyl rotamers in nucleosides are discussed.
- Kline, Paul C.,Serianni, Anthony S.
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p. 324 - 330
(2007/10/02)
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- A VERY EFFICIENT AND STRAIGHFORWARD SYNTHESIS OF 1,3-DICHLORO 1,1,3,3-TETRAISOPROPYLDISILOXANE
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In the presence of catalytic amount of palladium on charcoal, acetyl chloride smoothly chlorinates TIDPSiH2 at room temperature to give TIDPSiCl2 in high yield and in a high state of purity.
- Zhang, H. X.,Guibe, F.,Balavoine, G.
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p. 1299 - 1308
(2007/10/02)
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- NUCLEIC ACID RELATED COMPOUNDS. 42. A GENERAL PROCEDURE FOR THE EFFICIENT DEOXYGENATION OF SECONDARY ALCOHOLS. REGIOSPECIFIC AND STEREOSELECTIVE CONVERSION OF RIBONUCLEOSIDES TO 2 prime -DEOXYNUCLEOSIDES.
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Treatment of unhindered secondary alcohols with phenoxythiocarbonyl chloride (phenyl chlorothionocarbonate) in pyridine/dichloromethane, or in acetonitrile with 4-dimethylaminopyridine catalysis for hindered alcohols, gave clean conversion to their O-phenoxythiocarbonyl derivatives. Reductive deoxygenation of these phenyl thionocarbonate esters proceeded smoothly, using tri-n-butyltin hydride and a free radical initiator in warm toluene. Overall conversion yields ranged from 57 to 78% for the naturally occurring nucleosides, nucleoside antibiotics, and methyl beta -D-ribofuranoside.
- Robins,Wilson,Hansske
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p. 4059 - 4065
(2007/10/02)
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