- TGF-beta receptor inhibitor
-
The invention provides a compound shown as a formula (I) and a pharmaceutical composition thereof. The compound shown as the formula (I) of the present invention is useful as a TGF-beta receptor inhibitor, particularly a TGF beta RI inhibitor, for example, in the prevention or treatment of various TGF beta RI (ALK5) mediated related diseases.
- -
-
Paragraph 0142-0144; 0151-0152
(2021/04/28)
-
- Novel N-dealkylation of N-alkyl sulfonamides and N,N-dialkyl sulfonamides with periodic acid catalyzed by chromium(III) acetate hydroxide
-
Chromium(III) acetate hydroxide has been found to be an efficient catalyst for N-dealkylation of N-alkyl sulfonamides and N,N-dialkyl sulfonamides to furnish sulfonamides in good to excellent yields with periodic acid in acetonitrile at room temperature.
- Xu, Liang,Zhang, Suhong,Trudell, Mark L.
-
p. 1901 - 1904
(2007/10/03)
-
- REACTION OF ORGANIC AZIDES WITH UNSATURATED COMPOUNDS XI. REARRANGEMENTS OF BICYCLIC TRIAZOLINES, OBTAINED FROM TAUTOMERIC 2,4,4-TRIMETHYL-AND 3,3,5-TRIMETHYL-1-METHOXYCYCLOPENTENES AND 4-METHYL-3-NITROBENZENESULFONYL AZIDE
-
The reaction of 4-methyl-3-nitrobenzenesulfonyl azide with the tautomeric 2,4,4-trimethyl- and 3,3,5-trimethyl-1-methoxycyclopentenes leads to the formation of the products from transformation of both triazolines in almost equal ratios.The less substituted triazoline is converted through the corresponding aziridine into the allylsulfonamide, while the more substituted triazoline rearranges preferentially to methyl N-arylsulfonyl-1,3,3-trimethylcyclobutanecarboximidate.
- Semenov, V. P.,Ogloblin, K. A.
-
p. 711 - 715
(2007/10/02)
-
- REACTION OF ORGANIC AZIDES WITH UNSATURATED COMPOUNDS. VIII. REARRANGEMENT OF Δ2-1,2,3-TRIAZOLINES, OBTAINED FROM ARENESULFONYL AZIDES AND β,β-DIMETHYL-4-METHOXYSTYRENE BY AN ARYL SHIFT
-
2-Methyl-2-propanal was found in the products from the reaction of arenesulfonyl azides with β,β-dimethyl-4-methoxystyrene after hydrolysis.This indicates that 1-arylsulfonyl-4,4-dimethyl-5--Δ2-1,2,3-triazolenes rearrange by an aryl and not a hydride shift.
- Semenov, V. P.,Andreeva, T. D.,Ogloblin, K. A.
-
p. 195 - 198
(2007/10/02)
-