- Substituted aminoquinolines as modulators of chemokine receptor activity
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The present invention is directed to aminoquinolines of Formula I: STR1 (wherein R 1, R 2, R 3, and R 4 are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptors CCR-1, CCR-2, CCR-2A, CCR-2B, CCR-3, CCR-4, CCR-5, CXCR-3, and/or CXCR-4.
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- Substituted 4,6-Diaminoquinolines as Inhibitors of C5a Receptor Binding
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The anaphylatoxin C5a is implicated in a number of inflammatory diseases.It is a highly cationic protein with 13 of 74 amino acids being either arginine or lysine.A search focusing on positively charged molecules, particularly amine-containing functionali
- Lanza, Thomas J.,Durette, Philippe L.,Rollins, Thomas,Siciliano, Salvatore,Cianciarulo, Dana N.,et al.
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p. 252 - 258
(2007/10/02)
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