Synthesis and antihypertensive activity of novel 6-substituted-3-pyridazinylhydrazones
The synthesis and hypotensive properties of a series of 6-substituted-3-pyridazinylhydrazones are described. The most active compound of the series. 1-(6-morpholino-3-pyridazinyl)-2-[1-(tert-butoxycarbonyl)-2-propylidene] hydrazine, is a more potent hypotensive agent than hydralazine with a longer duration of action and a lower toxicity. Structure-activity relationships are discussed.
Szilagyi,Kasztreiner,Matyus,et al.
p. 111 - 117
(2007/10/02)
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