- Optimizing Pyrazolopyrimidine Inhibitors of Calcium Dependent Protein Kinase 1 for Treatment of Acute and Chronic Toxoplasmosis
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Calcium dependent protein kinase 1 (CDPK1) is an essential Ser/Thr kinase that controls invasion and egress by the protozoan parasite Toxoplasma gondii. The Gly gatekeeper of CDPK1 makes it exquisitely sensitive to inhibition by small molecule 1H-pyrazolo
- Janetka, James W.,Hopper, Allen T.,Yang, Ziping,Barks, Jennifer,Dhason, Mary Savari,Wang, Qiuling,Sibley, L. David
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supporting information
p. 6144 - 6163
(2020/07/10)
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- Imine derivatives as new potent and selective CB2 cannabinoid receptor agonists with an analgesic action
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In this study, a novel series of CB2 receptor agonist imine derivatives, 1-6, was synthesized and evaluated for activity against the CB2 receptor. In a previous paper we reported the synthesis and SARs of thiazole derivative 1, a pot
- Ohta, Hiroshi,Ishizaka, Tomoko,Tatsuzuki, Makoto,Yoshinaga, Mitsukane,Iida, Izumi,Yamaguchi, Tomomi,Tomishima, Yasumitsu,Futaki, Nobuko,Toda, Yoshihisa,Saito, Shuji
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p. 1111 - 1124
(2008/09/17)
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- IMINE COMPOUND
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An imine compound represented by the formula: wherein A represents a heterocyclic group; R1, R2, an R3 each represent a hydrogen atom, a halogen atom, a C1-10 alkyl group optionally substituted with an aryl grou
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Page/Page column 36-37
(2008/06/13)
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- Enantioselective synthesis of pentacycloanammoxic acid
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A highly effective enantioselective synthesis of pentacycloanammoxic acid (1), an unusual naturally occurring fatty acid from Candidatus Brocadia anammoxidans, has been accomplished. The C20-structure of 1 was assembled with stereocontrol from four building blocks, cyclobutene, 2-cyclopentenone, the chiral silylcyclopentenone 6, and 7-bromoheptanoic acid. Both 1 and its enantiomer are now available in quantities that should facilitate future studies on the mode of biosynthesis which appears to be unprecedented. Copyright
- Mascitti, Vincent,Corey
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p. 3118 - 3119
(2007/10/03)
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- Triazolecarboxamide herbicides
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Compounds of the formula: STR1 wherein X is O or S; R and R1 are substituted or unsubstituted alkyl, alkenyl, alkynyl or cycloalkyl or R and R1 may be joined to form a heterocyclic ring; R2 is substituted or unsubstituted cycloalkyl; and n is 0, 1 or 2 are disclosed as well as their postemergence and preemergence selective herbicide use against both monocot and dicot weeds in crops such as sugarbeets, cotton, soybeans and rice.
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