- PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS
-
The present disclosure provides phosphatidylinositol 3-kinase (PI3K) inhibitors of formula (J), or pharmaceutically acceptable salts thereof, in which A, n, m, R1, R2, R3 R4, R5, R6 and R7 are as defined herein. These compounds are useful for treatment of conditions mediated by one or more ΡI3Κ isoforms. The present disclosure further provides pharmaceutical compositions that include a compound of formula (J), or pharmaceutically acceptable salts thereof, and methods of using these compounds and compositions to treat conditions mediated by one or more PI3K isoforms.
- -
-
Paragraph 00237; 00238
(2016/01/25)
-
- 2,4,6-Trifluoropyrimidine. Reactions with nitrogen nucleophiles
-
In a continuation of our studies involving the nucleophilic displacement of one of the chlorines from 2,4,6-trichloropyrimidine, we now report the initial displacement of one of the fluorine atoms from 2,4,6-trifluoropyrimidine using both aliphatic and aromatic amines. The monosubstitution products favor 2-substitution with ammonia and ethanolamine while aniline gave the 4-substituted derivative as the preferred product.
- Delia, Thomas J.,Anderson, Dennis P.,Schomaker, Jennifer M.
-
p. 991 - 993
(2007/10/03)
-