- Effective synthesis of novel dihydrobenzisoxazoles bearing the 2-aminothiazole moiety and evaluation of the antiproliferative activity of their acylated derivatives
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An effective method for the synthesis of 8-aryl-4,5-dihydrothiazolo[4′,5′:3,4]benzo[1,2-c]isoxazol-2-amines was developed. This method includes the α-keto bromination of 3-aryl-6,7-dihydrobenzo[c]isoxazol-4(5H)-ones followed by the condensation of the obt
- Khlebnicova, Tatyana S.,Lakhvich, Fedor A.,Matous, Anton E.,Piven, Yuri A.,Scherbakov, Alexander M.,Shchegolev, Yuri Yu.,Sorokin, Danila V.,Yastrebova, Margarita A.,Zinovich, Veronica G.
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supporting information
p. 10432 - 10443
(2021/12/17)
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- Pd-catalyzed carbonylation for the construction of tertiary and quaternary carbon centers with sp3 carbon partners
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The first examples of a Pd-catalyzed carbonylation of aryl boronic acids with sp3 carbon partners are presented. Various boronic acids were shown to react with 1,3-diesters and 1,3-diketones to afford structurally unique carbonyl compounds. By
- Lu, Wei,Li, Yang,Wang, Chao,Xue, Dong,Chen, Jian-Gang,Xiao, Jianliang
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supporting information
p. 5243 - 5249
(2014/07/08)
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- NEW AMINOPYRAZOLOQUINAZOLINES
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The present invention encompasses compounds of general formula (I) wherein the groups R1 to R3 and X are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferatio
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Page/Page column 53-54
(2012/02/05)
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- AMINOPYRAZOLOQUINAZOLINES
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Compounds of general formula (I) wherein the groups R1 to R3 and X are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, pharmaceutical preparations whi
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Page/Page column 22
(2012/09/25)
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- SmCl3-catalyzed C-acylation of 1,3-dicarbonyl compounds and malononitrile
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(Chemical Equation Presented) A recyclable, convenient, and efficient catalytic system for C-acylation of 1,3-dicarbonyl compounds and malononitrile with acid chlorides has been developed, giving moderate to excellent yields under mild conditions. This is the first catalytic example of such reactions. In addition, by applying this protocol as the key step, 3,5-disubstituted-1H- pyrazole-4-carboxylate can easily be synthesized in high yields in a one-pot procedure.
- Shen, Quansheng,Huang, Wen,Wang, Jialiang,Zhou, Xigeng
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p. 4491 - 4494
(2008/03/12)
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- Method for acylating cyclic compounds
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The method of this invention prepares acylated cyclic compounds by contacting phenyl esters as acylating agents with cyclic compounds in the presence of a cyanide or fluoride catalyst.
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- Process for the preparation of acylated cyclic 1,3-dicarbonyl compounds
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A process for preparing a compound of Formula (I); where Q completes an optionally substituted 5-or 6-member saturated carbocyclic ring and R is optionally substituted phenyl or optionally substituted C3-C6 cycloalkyl which comprises the rearrangement of a compound of Formula (II); where Q and R are as defined in relation to Formula (I) in a polar aprotic, dipolar aprotic or aromatic hydrocarbon solvent in the presence of a moderate base and an azole.
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- SAR studies of 2-o-substituted-benzoyl- and 2-alkanoyl-cyclohexane-1,3-diones as inhibitors of 4-hydroxyphenylpyruvate dioxygenase
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Inhibition studies of 4-hydroxyphenylpyruvate dioxygenase (HPPD) with various synthesized 2-o-substituted-benzoyl- and 2-alkanoyl-cyclohexane-1,3-diones suggest that the presence of a strongly electronegative group at the ortho position and the conformati
- Lin, Yung-Lung,Wu, Chung-Shieh,Lin, Shean-Woei,Yang, Ding-Yah
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p. 843 - 845
(2007/10/03)
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- Synthesis and Photocyclization of 2-Aroyl-3-methylcyclohex-2-enones
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Preparation and photocyclization of a number of 2-aroyl-3-methylcyclohex-2-enones have been investigated.Irradiation of these systems resulted in a photo-enolization followed by a pericyclic reaction to give 3,4-dihydroanthracen-1(2H)-ones.Keywords - prep
- Tamura, Yasumitsu,Wada, Akimori,Okuyama, Shigehiro,Fukumori, Satoshi,Hayashi, Yoko,et al.
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p. 1312 - 1320
(2007/10/02)
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