- Anilinopyrimidine compound and medical use thereof
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The invention relates to an anilinopyrimidine represented by general formula (I), and a pharmaceutically acceptable salt, a solvate and a prodrug thereof. Substituent groups R1, R2, R3, R4, R5, R6, R7, R8, R9, Q and n in the general formula (I) are as def
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- Sila-condensed ring derivative and use and electroluminescent devices thereof
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The invention belongs to the technical field of application of photoelectric materials, and in particular relates to a sila-condensed ring derivative and use and electroluminescent devices thereof. Electronic transmission materials with high electron mobility characteristics are formed by bonding different aromatic groups at different sites of the sila-condensed ring derivative with a silicon-fused ring as a core or changing bridging structures. A Strong covalent bond is formed between silicon and a halogen by use of the sila-condensed ring derivative as an electron transport layer, and has astrong electron-drawing effect. The sila-seven membered ring can retain the characteristics of an aromatic ring, meanwhile a non-planar structure formed by sp3 hybridization of the silicon can effectively reduce the entire molecular plane accumulation, the sila-condensed ring derivative has a high triplet state, triplet exciton pass-back can be avoided, and the sila-condensed ring derivative is suitable for fluorescence emitting and phosphorescent light emitting systems.
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- Method for preparing mepanipyrim
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The invention provides a preparation method of mepanipyrim and belongs to the field of pesticide chemical synthesis technologies. The preparation method of the mepanipyrim comprises the following steps: firstly, reacting phenyl guanidine salt with ethyl acetoacetate so as to prepare phenylamino pyrimidone, reacting the phenylamino pyrimidone with phosphorus oxychloride so as to prepare 2-chloro-pyrimidine phenylamine; subsequently, carrying out coupling and crossing reaction between the 2-chloro-pyrimidine phenylamine and alkyne so as to prepare mepanipyrim. The preparation method of mepanipyrim has the advantages that the used raw materials and reagents are cheap and easily available; the reaction process is simple, the reaction conditions are mild, the cost is low, the yield is high, a good condition is created for industrial large-scale production and commercialization of the products.
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Paragraph 0014; 0017; 0022; 0027
(2018/07/30)
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- Synthesis, antimalarial activity, heme binding and docking studies of 4-aminoquinoline-pyrimidine based molecular hybrids
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A series of novel 4-aminoquinoline-pyrimidine hybrids was synthesized and evaluated for their antimalarial activity. Several compounds showed potent antimalarial activity against both CQ-sensitive and CQ-resistant strains of P. falciparum with no cytotoxi
- Kumar, Deepak,Khan, Shabana I.,Tekwani, Babu L.,Ponnan, Prija,Rawat, Diwan S.
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p. 63655 - 63669
(2015/02/19)
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- Effect of the structural modification of 2-benzylamino-4-(4-iodophenyl) amino-6-methylpyrimidine on the biological activity of its derivatives
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Abstract-Modification of the aliphatic-aromatic moiety in the 2-benzylmino-4-(4-iodophenyl)amino-6- methylpyrimidine leads to a change in the site of biological action of the formed structural analogs. Pleiades Publishing, Ltd., 2012.
- Erkin,Krutikov
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p. 1567 - 1572
(2013/01/15)
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