- Bifunctional chelating agents
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The invention related to a method of preparing a protein or a proteinaceous material labelled with a metalradionuclide and intended for diagnostic or therapeutic application, by reacting a protein or a proteinaceous material with an agent for coupling the radionuclide to the protein or the proteinaceous material, a protein conjugate being formed, and by then complexing the radionuclide with the conjugate thus formed to a radionuclide complex. A coupling agent is used which consists at least substantially of a thio compound of the general formula wherein X is a hydrogen atom or a suitable protective group, R is a branched or non-branched, optionally substituted hydrocarbon radical having 1-10 carbon atoms, which may be interrupted by one or more hereto atoms, and Y is at least one terminal reactive group capable of reacting with a functional group from the protein or the proteinaceous material; or a cyclic condensation product of the thio compound of formula I having 5-7 ring atoms, wherein X and Y together constitute a reactive group capable of reacting with a functional group from the protein or the proteinaceous material; or a water-soluble salt of this condensation product.
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- Hydrogen Bonds involving Polar CH Groups. Part 9. Optimum Structural Parameters, and Unequivocal Demonstration of such Intramolecular Interactions in 2-Substituted 1,3-Dithian 1,1,3,3-Tetraoxides
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A series of 2-monosubstituted 1,3-dithian 1,1,3,3-tetraoxides have been prepared, having side chains with 2-6 carbon atoms, and bearing alkyl, aryl, methoxy, dialkylamino, and pyridyl terminal substituents, as models for intramolecular C-H...X hydrogen bonds.Methoxy- and amino-substituents, in compounds having two or three carbon atoms in the side chain, show significant intramolecular interaction with the disulphone methine hydrogen in dichloromethane, as evidenced by a downfield shift of the 1H n.m.r. signals; shifts of up to 2.0 p.p.m. have been observed.Intramolecular H-bonds are disrupted in acetone and in pyridine owing to competing intermolecular interactions with the solvents, and in trifluoroacetic acid owing to protonation of the donor atom.
- Li, Chuen,Sammes, Michael P.
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p. 1303 - 1310
(2007/10/02)
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