Fusidic acid ring B hydroxylation by Cunninghamella elegans
Fusidic acid (1) biotransformation using the fungus Cunninghamella elegans NRRL 1392 was studied. Two hydroxylated derivatives of fusidic acid (2, 3) were isolated, and their structures were fully elucidated using various spectroscopic techniques includin
Ibrahim, Abdel-Rahim S.,Ragab, Amany E.
p. 86 - 89
(2018/04/14)
PREPARATION OF A CRYSTALLINE ANTIBIOTIC SUBSTANCE
The present invention relates to processes for the crystallisation and for the preparation and isolation of a novel crystalline form of fusidic acid, to the use of said processes in the manufacture of pharmaceutical formulation or medicament, and to the use of said crystalline fusidic acid form for the treatment of bacterial infections.
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Page/Page column 33-34
(2008/06/13)
Glycosylated analogs of fusidic acid
Novel analogs of fusidic acid are described with one or more carbohydrate units attached. Certain glycosylated analogs of fusidic acid have enhanced solubility properties in diluents or excipient of choice as compared to unmodified fusidic acid. Certain glycosylated analogs may be employed as chemotherapeutic agents and particular analogs may be useful for fighting anti-microbial infections.
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(2008/06/13)
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