cas 700844-09-3, 7-CHLOROTHIENO[3,2-B]PYRIDINE-6-CARBONITRILE | Articles data ｜lookchem

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700844-09-3

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FUSED MULTICYCLIC COMPOUNDS AS PROTEIN KINASE INHIBITORS
Fused multicyclic compounds of formula (I): wherein R′, R″, X, Y, Z, A, B, C, D, and n are defined herein. Also disclosed are a method for inhibiting protein kinase (e.g., Aurora kinase) activity and a method for treating a protein kinase mediated disorde
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Page/Page column 55

(2010/04/25)

Thieno[3,2-b]pyridine-6-carbonitriles and thieno[2,3-b]pyridine-5-carbonitriles as protein kinase inhibitors
This invention provides compounds of Formula (1a)-(1f), II wherein: X, m, n, q, R1, R2, R3, R4, R5, R6, R7, R8, R9, Y, Q, Z, Z′, Z′″, Z″ and J are defined hereinbefore in the specification, which are useful in the treatment of cancer, stroke, myocardial infarction, neuropathic pain, osteoporosis, polycystic kidney disease, autoimmune disease, rheumatoid arthritis, and transplant rejection and process for producing said compounds.
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(2008/06/13)

THIENO[3,2-b]PYRIDINE-6-CARBONITRILES AND THIENO[2,3-b]PYRIDINE-5-CARBONITRILES AS PROTEIN KINASE INHIBITORS
This invention provides compounds of Formula (1 a) - (1f) wherein:X, R1, and R2 are defined hereinbefore in the specification, which are useful in the treatment of cancer, stroke, osteoporosis, polycystic kidney disease, autoimmune disease, rheumatoid arthritis, and transplant rejection and process for producing said compounds.
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Page 75

(2010/02/07)

Identification of 7-phenylaminothieno-[3,2-b]pyridine-6-carbonitriles as a new class of Src kinase inhibitors
We disclose here a new class of kinase inhibitors, obtained by replacing the phenyl ring of a 3-quinolinecarbonitrile system with a thiophene ring. When suitably substituted, the resultant 7-phenylaminothieno[3,2-b]pyridine-6- carbonitrile analogues show
Boschelli, Diane H.,Wu, Biqi,Sosa, Ana Carolina Barrios,Durutlic, Haris,Ye, Fei,Raifeld, Yuri,Golas, Jennifer M.,Boschelli, Frank
p. 6666 - 6668
(2007/10/03)

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Chemical Properties

Melting Point: 105-107 °C
Boiling Point: 354.2°C at 760 mmHg
Flash Point:168°C
Density: 1.51
Storage Temp.:2-8°C(protect from light)
Vapor Pressure: 3.39E-05mmHg at 25°C
Refractive Index: 1.7
PKA: 0.81±0.40(Predicted)
PSA: 64.92000
LogP: 2.82138

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