Novel coordinating motifs for lanthanide(III) ions based on 5-(2-pyridyl)tetrazole and 5-(2-pyridyl-1-oxide)tetrazole. Potential new contrast agents
Water-soluble and neutral Ln(III) and Zn (II) complexes of pyridine- and (pyridine-1-oxide)tetrazole have been synthesized and the Gd derivatives have great potential as high-relaxivity low-osmolarity MRI contrast agents.
Facchetti, Antonio,Abbotto, Alessandro,Beverina, Luca,Bradamante, Silvia,Mariani, Palma,Stern, Charlotte L.,Marks, Tobin J.,Vacca, Alberto,Pagani, Giorgio A.
p. 1770 - 1771
(2007/10/03)
PHARMACEUTICAL COMBINATION
There is provided a combination product comprising: (1) a compound of claim 1 in WO 02/44145 or a compound of claim 20 in WO 02/44145 (or derivative thereof)or a pharmaceutically-acceptable derivative thereof; and (1) a compound as defined in claim 1 of WO 01/28992 or (2) a compound of Claim 34 of WO 01/28992 or (3) Compound A or B or C or D (or pharmaceutically-acceptable salts thereof) for use in treating arrhythmia or a coagulation controlled complication thereof.
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Page 113; 114
(2010/02/04)
Fused bicyclic Gly-Asp β-turn mimics with potent affinity for GPIIb-IIIa. Exploration of the arginine isostere
6-[4-Amidinobenzoyl]amino]-tetralone-2-acetic acid is a potent antagonist of GPIIb-IIIa. Substitution in the meta position of the benzamidine, or replacement with a heteroaryl amidine was tolerated in this series. Use of an acyl-linked 4-alkyl piperidine
Fisher, Matthew J.,Giese, Ulrich,Harms, Cathy S.,Kinnick, Michael D.,Lindstrom, Terry D.,McCowan, Jefferson R.,Mest, Hans-Juergen,Morin Jr., John M.,Mullaney, Jeffrey T.,Paal, Michael,Rapp, Achim,Ruehter, Gerd,Ruterbories, Ken J.,Sall, Daniel J.,Scarborough, Robert M.,Schotten, Theo,Stenzel, Wolfgang,Towner, Richard D.,Um, Suzane L.,Utterback, Barbara G.,Wyss, Virginia L.,Jakubowski, Joseph A.
p. 385 - 389
(2007/10/03)
Phamacologically active 5-carboxy-2-(5-tetrazolyl) pyridines
Compounds of the formula I STR1 wherein the groups A, R1, R2 and R3 are as defined in the specification, exhibit valuable pharmacological properties, especially as antifibrotic agents. They are prepared by methods known pe
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(2008/06/13)
Trimethylsilanol as Leaving Group; III. A Simple One-Step Conversion of Aromatic Heterocyclic N-Oxides to α-Cyano Aromatic N-Heterocycles
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Vorbrueggen, Helmut,Krolikiewicz, Konrad
p. 316 - 319
(2007/10/02)
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