- Asymmetric palladium(II)-catalyzed cascade reaction giving quaternary amino succinimides by 1,4-addition and a nef-type reaction
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Simple starting materials, high-value products: A dinuclear ferrocene-based PdII complex transforms mixtures of racemic N-benzoyl α-amino acids, nitroolefins, acetic anhydride, and manganese acetate into biologically interesting quaternary amin
- Weber, Manuel,Frey, Wolfgang,Peters, Rene
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- Direct introduction of glycine/mercaptoacetic acid units into electron-poor alkenes: a novel route to functionally rich α-amino/α-mercapto acids
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The first example of an operationally simple direct introduction of glycine/mercaptoacetic acid units into electron-poor alkenes is reported. In this protocol, Lewis acid-catalyzed Michael addition of activated glycine or mercaptoacetic acid, that is 2-phenyl-1,3-oxazol-5-one or 2-methyl-2-phenyl-1,3-oxathiolan-5-one, to various electron-poor alkenes in water/1,4-dioxane (1:2, v/v) solvent system diastereoselectively affords the corresponding functionally rich α-amino acids or α-mercapto acids, respectively, in high yields at ambient temperature.
- Yadav, Lal Dhar S.,Rai, Ankita
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p. 5751 - 5754
(2008/12/22)
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