- Substituted 1,5-cyclohexadiene carboxylic acid derivatives
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Compounds of the following general formula and salts thereof are irreversible inhibitors of γ-aminobutyric acid transaminase: STR1 wherein R1 is hydrogen, alkylcarbonyl wherein the alkyl moiety has from 1 to 4 carbon atoms and is straight or branched, alkoxycarbonyl wherein the alkoxy moiety has from 1 to 4 carbon atoms and is straight or branched, the radical STR2 wherein R4 is hydrogen, a straight or branched alkyl group having from 1 to 4 carbon atoms, benzyl or p-hydroxybenzyl; R2 is hydroxy, a straight or branched alkoxy group of from 1 to 8 carbon atoms, the group wherein each of R5 and R6 is hydrogen or a straight or branched alkyl group having from 1 to 4 carbon atoms, or STR3 wherein R7 is hydrogen, a straight or branched lower alkyl group of from 1 to 4 carbon atoms, benzyl or p-hydroxybenzyl; and R3 is hydrogen or bromine.
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