- AROMATIC RING COMPOUND
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The present invention provides a compound having a GOAT inhibitory action, which is useful for the prophylaxis or treatment of obesity and the like, and has superior efficacy. The present invention is a compound represented by the formula (I): wherein eac
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Paragraph 0484
(2013/09/12)
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- NICOTINIC ACID CROWN ETHERS: SYNTHESIS, COMPLEXATION AND REDUCTION
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2,6-Bis(bromomethyl)nicotinic oxazoline (15), prepared from ethyl 2,6-dimethylnicotinate, was converted into the 1:1-macrocyclic oxazolines 19 and 22 as well as the isomeric macrocyclic dimers 20.Ethyl 2,6-bis(bromomethyl)nicotinate (23), prepared from 6b, was converted to the corresponding 1:1-dibenzo-18-crown-6 macrocyclic analog 24.NMR and mass spectral data were used to ascertain the macrocyclic structures.Reaction of 22 with EtMgBr afforded, after oxidation, the 4-substituted pyridino macrocycle 26 in high yield.However, under identical conditions, the non-oxazoline macrocycle 27 was recovered in toto.
- Newkome, George R.,Marston, Charles R.
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p. 2001 - 2008
(2007/10/02)
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