Sterol regulatory element binding protein and acidic nucleoplasm DNA binding protein-1 inhibitor, preparation method and application thereof
The invention discloses a compound which is shown as formula I and can inhibit sterol regulatory element binding protein (Srebp) and acidic nucleoplasm DNA binding protein-1 (And-1, WDHD1), a preparation method and application thereof. RT-PCR (reverse transcription-polymerase chain reaction) and immunoblotting experiments show that the compound can remarkably reduce the expression of a Srebp downstream gene SCD-1 and inhibit the activity of And-1 protein. Further experiments show that the compound has a proliferation inhibition effect on various tumor cells. The compound shown as formula I isexpected to become a novel anti-tumor drug and a tumor chemoradiotherapy sensitizing drug.
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Paragraph 0060-0063; 0077-0079
(2020/07/13)
Direct C-H bond arylation of 2-hydroxybenzaldehydes with arylboronic acids via ligand-free palladium catalysis
A mild and efficient ligand-free palladium-catalyzed direct C-H bond arylation reaction was developed to afford 2-hydroxybenzophenones in good to excellent yields from easily available 2-hydroxybenzaldehydes and arylboronic acids. The given reaction provided one of the easiest pathways for accessing 2-hydroxybenzophenones, and a variety of functional groups could be tolerated in this process.
Weng, Fei,Wang, Chengming,Xu, Bin
supporting information; experimental part
p. 2593 - 2596
(2010/07/04)
An efficient and convenient synthesis of 5-formylsalicylaldehyde
5-Formylsalicylaldehyde 1, which is a key intermediate of spiropyran dye and a recently developed insulin sensitivity enhancer (ISE) compounds, was prepared from 5-iodosalicylaldehyde by the palladium-catalyzed coupling reaction with ethyl acrylate follow
Lee, Seung Hwan,Cho, Young Jin,Bae, Jong Woo,Yoon, Cheol Min
p. 1003 - 1008
(2007/10/03)
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