- New Options of Multicomponent Condensations Leading to Functional Derivatives of 2-Pyridons
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Abstract: Multicomponent condensations of activated olefins, functionalized CH-acids, and alkylating reagents, which open up the possibility of preparing derivatives of substituted 2-pyridones, have been studied. The structure of some compounds has been c
- Dorovatovskii, P. V.,Dyachenko, I. V.,Dyachenko, V. D.,Khrustalev, V. N.,Nenaidenko, V. G.
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p. 1809 - 1823
(2021/12/22)
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- Synthesis of 2-cyanoacrylamides through Pd-catalyzed monohydration of methylenemalononitriles
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A straightforward and efficient method has been developed for the synthesis of 2-cyanoacrylamide from 2-methylenemalononitriles through monohydration. A series of methylenemalononitriles underwent the reaction under mild and simple reaction conditions wit
- Liu, Yingtian,Dang, Xinxin,He, Yu,Bai, Hudong,Chen, Xuehong,Li, Jun-Long,Fan, Junting,Jiang, Hezhong,Li, Jiahong
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p. 662 - 671
(2019/02/20)
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- Tetrahydro benzothiophene derivative and application thereof to preparation of glycogen synthase kinase 3 beta inhibitor
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The invention discloses a tetrahydro benzothiophene derivative and the application thereof to the preparation of a glycogen synthase kinase 3 beta inhibitor. The tetrahydro benzothiophene derivative, pharmaceutically acceptable salt, optical active body or racemate thereof has a chemical structure as shown in a formula I. Experiments show that the compound has good GSK-3 beta inhibitory activity. In addition, the invention further provides a method for preparing a tetrahydro benzothiophene compound. The method is short in synthesis route, simple in preparation process and easy to operate, and can meet the requirements of large-scale industrial production.
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Paragraph 0044; 0045; 0046
(2017/10/25)
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- Homogeneous and stereoselective copper(II)-catalyzed monohydration of methylenemalononitriles to 2-cyanoacrylamides
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A facile and efficient route for the homogeneous and highly stereoselective monohydration of substituted methylenemalononitriles to (E)-2-cyanoacrylamides catalyzed by copper(II) acetate monohydrate in acetic acid containing 2% water is described, and a mechanism is proposed. The protocol has proved to be suitable for the monohydration of dicyanobenzenes and 2-substituted malononitriles.
- Xin, Xiaoqing,Xiang, Dexuan,Yang, Jiming,Zhang, Qian,Zhou, Fenguo,Dong, Dewen
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p. 11956 - 11961
(2014/01/06)
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- Synthesis of some 3-substituted amino-4,5-tetramethylene thieno[2,3-d][ 1,2,3]-triazin-4(3H)-ones as potential antimicrobial agents
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A series of 3-Substituted amino-4,5-tetramethylene thieno[2,3-d] [1,2,3]-triazine-4(3H)-ones have been synthesized and characterized by UV,IR, 1H NMR, elemental and mass spectral analysis. The title compounds were evaluated for their antimicrobial activit
- Saravanan, Janardhanan,Mohan, Shamanna,Roy, Jay Jyoti
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experimental part
p. 4365 - 4369
(2010/10/02)
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- PROCESS FOR PREPARING CYCLOHEXANEDIACETIC ACID MONOAMIDE
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A new process is described for synthesising cyclohexanediacetic acid monoamide, a key compound in the synthesis of grabapentin precursors. The process of the invention is characterised by reacting cyclohexanone with cynoacetamide and immediately after, with a suitable malonic acid ester. A new intermediate (5-cyano-2,4-dioxo-3-azaspiro[5,5]undecane-1-carboxylic acid ester) is obtained which is convertible, under mild reaction conditions, into cyclohexanediacetic acid monoamide.
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Page/Page column 6
(2010/02/14)
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- Synthesis of Cyclobutenes by the Novel Photochemical Ring Contraction of 4-Substituted 2-Amino-3,5-dicyao-6-phenyl-4H-pyrans
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4-Substituted 2-amino-3,5-dicyano-6-phenyl-4H-pyrans undergo a novel photochemical ring contraction to cyclobutenes from the triplet state.For example, irradiation of a solution of 2-amino-3,5-dicyano-6-phenyl-4H-pyran-4-spirocyclopentane (9a) in methylen
- Armesto, Diego,Horspool, William M.,Martin, Nazario,Ramos, Ana,Seoane, Carlos
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p. 3069 - 3072
(2007/10/02)
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- A Novel Photochemical Ring Contraction of 4H-Pyrans. A New Route to Selectively Substituted Cyclobutenes
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The novel photochemical ring contraction of some 4H-pyrans to cyclobutenes is described.
- Armesto, Diego,Horspool, William M.,Martin, Nazario,Ramos, Ana,Seoane, Carlos
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p. 1231 - 1232
(2007/10/02)
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