- PYRIDINE DERIVATIVE
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Provided is a pyridine derivative represented by formula (I), a prodrug thereof, a pharmaceutically acceptable salt of the pyridine derivative or the prodrug, or a solvate of the pyridine derivative, the prodrug or the pharmaceutically acceptable salt, wh
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Paragraph 0216; 0217; 0218
(2015/10/28)
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- IMIDAZOPYRROLIDINONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE
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The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
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Page/Page column 109; 110; 114
(2014/12/12)
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- Synthesis of 2-bromo-7-methyl-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one and 3-alkyl-2-bromo-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one and their selective elaboration
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Two synthetic routes to the versatile 3,5-dihydro-imidazo[4,5-d]pyridazin-4-ones 2 and 5 have been developed that allow the production of multigram quantities without the need of any chromatographic purification. Broad and selective elaboration of the heteroaromatic scaffolds has also been accomplished.
- Eckhardt, Matthias,Hauel, Norbert,Langkopf, Elke,Himmelsbach, Frank
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p. 1931 - 1934
(2008/09/19)
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- Chemical and biological effects of substitution of the 2-position of ring-expanded ('fat') nucleosides containing the imidazo[4,5-e][1,3]diazepine-4,8-dione ring system: The role of electronic and steric factors on glycosidic bond stability and anti-HCV a
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The attempted removal of the aralkyl group of 2-bromo-1-p-methoxybenzyl-6-octylimidazo[4,5-e][1,3]diazepine (ZP-33) with trifluoroacetic acid resulted in replacement of the bromo group with a carbonyl at position-2 in addition to the desired deprotection
- Zhang, Peng,Zhang, Ning,Buckwold, Victor E.,Hosmane, Ramachandra S.
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p. 4933 - 4945
(2008/03/15)
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- Imidazopyridazinediones, their preparation and their use as pharmaceutical compositions
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The invention relates to substituted imidazopyridazinediones of general formula wherein R1 and R4 are defined as in claim 1, the tautomers, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof, which have va
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Page/Page column 9
(2008/06/13)
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- IMIDAZOPYRIDAZINE DIONES, THE PRODUCTION THEREOF, AND THE USE OF THE SAME AS A MEDICAMENT
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The invention relates to substituted imidazopyridazine diones of general formula (I) wherein R1 to R4 have the designation defined in patent claim 1. The invention also relates to the tautomers, enantiomers, diastereomers, mixtures and salts of said dione
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Page/Page column 27
(2008/06/13)
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- Imidazole derivatives, their preparation and their use as intermediates for the preparation of pharmaceutical compositions and pesticides
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The invention relates to new substituted imidazoles of general formula wherein R1 to R3 and X are defined as in the claims, the tautomers, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof, and processes for preparing them and their use as intermediates for preparing pharmaceutical compositions or pesticides.
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Page/Page column 8
(2008/06/13)
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- NOVEL IMIDAZOLE DERIVATIVES, THE PRODUCTION THEREOF, AND THE USE OF THE SAME AS INTERMEDIATE PRODUCTS FOR PRODUCING MEDICAMENTS AND PESTICIDES
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The invention relates to novel substituted imidazoles of general formula (I) wherein R1 to R3 and X have the designations cited in the patent claims. The invention also relates to the tautomers, enantiomers, diastereromers, mixtures, and salts of said imidazoles, to methods for the production thereof, and to the use of the same as intermediate products for producing medicaments or pesticides.
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Page/Page column 22
(2008/06/13)
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- New imidazopyridazinone and imidazopyridone derivatives, the preparation thereof and their use as pharmaceutical compositions
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The present invention relates to substituted imidazo-pyridinones and imidazo-pyridazinones of general formula wherein Y and R1 to R4 are defined as in claim 1, the tautomers, enantiomers, diastereomers, the mixtures thereof and the salts thereof, which have valuable pharmacological properties, particularly an inhibiting effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).
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Page/Page column 14
(2008/06/13)
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- Synthesis and in vitro anti-hepatitis B and C virus activities of ring-expanded ('fat') nucleobase analogues containing the imidazo[4,5-e][1,3] diazepine-4,8-dione ring system
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As part of our structure-activity relationship studies, we report here the synthesis and in vitro anti-HBV and anti-HCV activities of a number of ring-expanded ('fat') nucleobases containing the imidazo[4,5-e][1,3]diazepine-4, 8-dione ring system. One of
- Zhang, Peng,Zhang, Ning,Korba, Brent E.,Hosmane, Ramachandra S.
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p. 5397 - 5401
(2007/10/03)
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- IMIDAZO-PYRIDAZINONE DERIVATIVES AND IMIDAZO-PYRIDONE DERIVATIVES, PRODUCTION THEREOF, AND USE THEREOF AS MEDICAMENTS
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The invention relates to substituted imidazo-pyridinones and imidazo-pyridazinones of general formula (I), wherein Y and R1 to R4 are defined as indicated in claim 1, the tautomers, enantiomers, diastereomers, mixtures, and salts thereof that have valuable pharmacological properties, especially an inhibiting effect on the activity of the dipeptidyl peptidase IV (DPP-IV) enzyme.
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Page/Page column 42
(2008/06/13)
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- 1H-IMIDAZO`4,5-D!PYRIDAZINES AS DPP-IV INHIBITORS FOR THE TREATMENT OF NIDDM
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A compound of the formula (I) or a pharmaceutically acceptable salt thereof: [wherein X and Y each is independently O, etc.; R1 and R2 each is independently H or (lower)alkyl; R3 is (lower)alkenyl, etc; R4 and R5 each is independently H or (lower)alkyl; n
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