- Synthetic method of 3-chloromethyl-1,2,4-triazolin-5-one
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The invention relates to a synthetic method of 3-chloromethyl-1,2,4-triazolin-5-one. The 3-chloromethyl-1,2,4-triazolin-5-one is prepared by mixing chloroacetonitrile, an alcohol and a solvent A. Compared with a conventional process, the synthesis method has the advantages that the raw materials with low price are selected, and production cost is remarkably reduced. For the whole technological process, the synthetic route is shortened, and production efficiency is improved. Production operation and quality control are more convenient while the production process is simplified.
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Paragraph 0017; 0018; 0021; 0022
(2019/04/26)
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- propyl trunk a kind of structure-containing alkoxy phenyl thiazole carboxylic acid amide type of dual-target inhibitors, process for their preparation and use
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The invention relates to the field of medicines related to type 2-diabetes mellitus, and particularly relates to an alkoxyphenyl thiazolecarboxylic acid amide non-glucoside SGLT2/SGLT1 double-target inhibitor containing a cyclopropyl amidine structure as well as a preparation method of the inhibitor and application of the inhibitor in preparation of medicines for treating type-2 diabetes mellitus. The structure is as shown in the specification, wherein R1 is selected from alkyl of C1-C5 and naphthenic base of C3-C6.
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Paragraph 0022; 0023; 0024
(2016/12/22)
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- propyl trunk structure containing a halogenated phenyl thiazole carboxylic acid amide compound and use thereof
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The invention relates to the field of type 2 diabetes-related medicaments. Specifically, the invention relates to a halogenated phenyl thiazolecarboxamide type non-glycoside SGLT2/SGLT1 double-target-point inhibitor containing a cyclopropyl amidine struct
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Paragraph 0023; 0024; 0025
(2016/10/10)
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- The nitrobenzene structure containing phenylamidines thiazole carboxylic acid amide compound and use thereof
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The invention relates to the field of medicines related to type II diabetes mellitus and in particular relates to nitrobenzothiazole carboxylic acid amide non-glucoside SGLT (sodium-glucose linked transporter)2/SGLT1 double-target inhibitors containing ph
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Paragraph 0020-0021
(2017/02/24)
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- A kind of structure including trunk alkoxy phenyl thiazole carboxylic acid amide type of dual-target inhibitors, process for their preparation and use
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The invention relates to the field of type 2 diabetes-related medicaments. Specifically, the invention relates to an alkoxyphenyl thiazolecarboxamide type non-glycoside SGLT2/SGLT1 double-target-point inhibitor containing an amidine structure, a preparati
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Paragraph 0021-0024
(2017/02/24)
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- The structure containing phenylamidines nitrile base benzene thiazole carboxylic acid amides, their preparation and use
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The invention relates to the field of type 2 diabetes-related medicaments. Specifically, the invention relates to a nitrile benzene thiazolecarboxamide type non-glycoside SGLT2/SGLT1 double-target-point inhibitor containing a phenyl amidine structure, a p
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Paragraph 0018; 0019; 0020; 0021
(2017/04/03)
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- Synthesis and metal complexes of chiral C2-symmetric diamino-bisoxazoline ligands
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A synthetic route to tetradentate chiral N4 ligands has been developed with the aim to study the potential of corresponding iron and manganese complexes as catalysts for enantioselective epoxidation. These ligands, which contain two oxazoline rings and two trialkylamino groups as coordinating units, are readily prepared in enantiomerically pure form by the reaction of chiral 2-chloromethyloxazolines with achiral N,N′- dimethylethane-1,2-diamine or chiral (R,R)-N,N′-dimethylcyclohexane-1,2- diamine. The ligands derived from N,N′-dimethylethane-1,2-diamine reacted with anhydrous metal halides MnCl2 and FeCl2 in a stereoselective manner to give octahedral mononuclear complexes that have the general formula Δ-[(L)MCl2]. In contrast, the ligands derived from N,N′-dimethylcyclohexane-1,2-diamine formed complexes with different coordination modes depending on the diastereomer employed: in one case the metal ion was found to be pentacoordinate, in the other case a hexacoordinated complex was observed. The structure of a series of Fe and Mn complexes was determined by X-ray analysis. The coordination chemistry of these ligands was further studied by X-ray and NMR analyses of the diamagnetic isostructural complexes [(L)ZnCl2]. Analogous ionic complexes, which were prepared by removing chloride with silver trifluoromethanesulfonate or hexafluoroantimonate, were tested as catalysts for the epoxidation of olefins.
- Guillemot, Geoffroy,Neuburger, Markus,Pfaltz, Andreas
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p. 8960 - 8970
(2008/09/17)
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- COMPOUNDS
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A compound of formula (I): compositions and medicaments containing the same as well as processes for the preparation and use of such compounds, compositions and medicaments, particularly in diseases associated with inappropriate Aurora activity.
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Page/Page column 48; 49
(2010/11/26)
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- A new synthesis of 1,2,4-triazolin-5-ones: Application to the convergent synthesis of an NK1 antagonist
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Chlorotriazolinone 4 has been synthesised in a single step via the novel condensation of semicarbazide hydrochloride with orthoester 8. Alkylation of secondary amine 3 with compound 4 proceeds in 99% yield to afford the target NK1 antagonist 1. (C) 2000 Published by Elsevier Science Ltd.
- Cowden,Wilson,Bishop,Cottrell,Davies,Dolling
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p. 8661 - 8664
(2007/10/03)
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- REACTION OF ISOPROPYLIDENE MALONATE WITH CHLOROIMIDATES. A REGIOSPECIFIC FORMATION OF CYCLIC N-ACYLATED β-ENAMINO ESTERS.
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A regiospecific formation of glutarimide and succinimide derivatives is observed by reaction of Meldrum's acid with chloroimidates.
- Kapron, P.,Lhommet, G.,Maitte, P.
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p. 2255 - 2258
(2007/10/02)
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