The invention belongs to the field of medical chemistry, relates to a 2,4-dibasic miazines compound and specifically relates to a compound shown as formula (I) or a pharmaceutically acceptable salt thereof, a drug compound thereof and an application thereof in treating EGFR or/and ALK mediated diseases.
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Paragraph 0178; 0182; 0183; 0184; 0185
(2017/08/29)
COMPOUNDS FOR INHIBITING CELL PROLIFERATION IN EGFR-DRIVEN CANCERS
The invention features compounds, pharmaceutical compositions and methods for treating patients who have an EGFR-driven cancer of formula (I), wherein the variables are as defined herein.
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Page/Page column 55
(2012/11/14)
Synthesis of crescent aromatic oligoamides
This article describes the synthetic procedures for the preparation of crescent (and helical) aromatic oligoamides developed in recent years in our laboratory. The large-scale preparation of a variety of monomers derived from various tetrasubstituted benzenes is presented. Three different strategies for constructing various oligomers consisting of meta- and meta/para-linked benzene residues are discussed. Factors affecting coupling efficiency and yields are analyzed. The developed synthetic methods have provided the basis for the preparation of longer oligomers and for the development of solid-phase synthesis.
Yuan, Lihua,Sanford, Adam R.,Feng, Wen,Zhang, Aimin,Zhu, Jin,Zeng, Huaqiang,Yamato, Kazuhiro,Li, Minfeng,Ferguson, Joseph S.,Gong, Bing
p. 10660 - 10669
(2007/10/03)
Positive allosteric modulators of the nicotinic acetylcholine receptor
The invention provides compounds of Formula I: These compounds may be in the form of pharmaceutical salts or compositions, may be in pure enantiomeric form or racemic mixtures, and are useful in pharmaceuticals used to treat diseases or conditions in which α7 nAChR is known to be involved.
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Page 32, 33
(2010/02/05)
Hypoxia-selective antitumor agents. 13. Effects of acridine substitution on the hypoxia-selective cytotoxicity and metabolic reduction of the bis- bioreductive agent nitracrine N-oxide
A series of nuclear-substituted derivatives of nitracrine N-oxide (2; a bis-bioreductive hypoxia-selective cytotoxin) were prepared and evaluated, seeking analogues of lower nitroacridine reduction potential. Disubstitution with Me or OMe groups at the 4-
Lee,Wilson,Ferry,Van Zijl,Pullen,Denny
p. 2508 - 2517
(2007/10/03)
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