- Alkyl 2-fluoro-1-methoxyethylcarbamates
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Alkyl esters of 2-fluoro-1-methoxyethylcarbamic acid, which are useful intermediates in the preparation of compounds, such as 4-amino-5- fluoropentanoic acid, are prepared by the electrochemical anodic oxidation of esters of 2-fluoroethylcarbamic acid in the presence of methanol and an electrolyte.
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- Halomethyl derivatives of gamma-aminobutyric acid and related compounds
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Novel compounds of the following general formula are useful pharmacological agents: STR1 wherein Y is FCH2 - or F2 CH-; R1 is hydroxy, a straight or branched alkoxy group of from 1 to 8 carbon atoms, -NR10 R11 wherein each of R10 and R11 is hydrogen or a straight or branched alkyl group of from 1 to 4 carbon atoms or STR2 wherein R12 is hydrogen, a straight or branched lower alkyl group of from 1 to 4 carbon atoms, benzyl or p-hydroxybenzyl; R2 is hydrogen, alkylcarbonyl wherein the alkyl moiety has from 1 to 4 carbon atoms and is straight or branched, alkoxycarbonyl wherein the alkoxy moiety has from 1 to 4 carbon atoms and is straight or branched or STR3 wherein R8 is hydrogen, a straight or branched lower alkyl group of from 1 to 4 carbon atoms, benzyl or p-hydroxybenzyl; and n is the integer 2 or 3; pharmaceutically acceptable salts and individual optical isomers thereof.
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