- Metal-free visible light-promoted synthesis of isothiazoles: A catalytic approach for N-S bond formation from iminyl radicals under batch and flow conditions
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A sustainable synthesis of isothiazoles has been developed using an α-amino-oxy acid auxiliary and applying photoredox catalysis. This simple strategy features mild conditions, broad scope and wide functional group tolerance representing a new enviromenta
- Alemán, José,Berton, Mateo,Cabrera-Afonso, María Jesús,Cembellín, Sara,Halima-Salem, Adnane,Maestro, M. Carmen,Marzo, Leyre,Miloudi, Abdellah
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p. 6792 - 6797
(2020/11/09)
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- Microwave-assisted synthesis of 3-methylisothiazolo[5,4-b]pyridine and various 2-amino derivatives of thieno[2,3-b]pyridine and 1-(2-aminopyridin-3-yl) ethanone
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Various 2-amino derivatives of thieno[2,3-b]pyridin-2-amine (3a-g) were prepared in fair to good yields (3076%) by subjecting 1-(2-chloro-pyridin-3-yl) ethanone (1) and appropriate primary amine (2a-g) to microwave heating at 90120 °C for 1520 min in the
- Ankati, Haribabu,Biehl, Edward R.
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experimental part
p. 1291 - 1302
(2010/10/05)
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- Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, pyrazolopyridines, isothiazolopyridines, and preparation and uses thereof
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The present invention relates generally to the field of ligands for nicotinic acetylcholine receptors (nACh receptors), activation of nACh receptors, and the treatment of disease conditions associated with defective or malfunctioning nicotinic acetylcholine receptors, especially of the brain. Further, this invention relates to novel compounds (e.g., indazoles and benzothiazoles), which act as ligands for the α7 nACh receptor subtype, methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.
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Page/Page column 75
(2010/11/26)
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- Synthetic Investigation on Isothiazolo-- and --pyridines
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Different approaches to the title ring systems were examined, based on the cleavage of the N-O bond in the isoxazolopyridine-4-thiols (3) and (4) which afforded the hydroxy derivatives (6) and (7), respectively, in moderate to good yields. 3-Methylisothiazolo-- and --pyridine (11) and (18), as well as several functionalized derivatives, were easily obtained from these key intermediates through the corresponding 4,6-dichloroisothiazolopyridines (10) and (17).
- Chimichi, Stefano,Nesi, Rodolfo,Ponticelli, Fabio,Tedeschi, Piero
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p. 1477 - 1480
(2007/10/02)
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