Synthesis and initial preclinical evaluation of the P2X7 receptor antagonist [11C]A-740003 as a novel tracer of neuroinflammation
Neuroinflammation, in particular activation of microglia, is thought to play an important role in the progression of neurodegenerative diseases. In activated microglia, the purinergic P2X7 receptor is upregulated. A-740003, a highly affine and
Janssen, Bieneke,Vugts, Danielle J.,Funke, Uta,Spaans, Arnold,Schuit, Robert C.,Kooijman, Esther,Rongen, Marissa,Perk, Lars R.,Lammertsma, Adriaan A.,Windhorst, Albert D.