- Antidiabetic furancarboxylic and thiphenecarboxylic acids
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Compounds of the structure STR1 wherein Z is oxygen or sulfur; R is (C1 -C2)alkoxy; phenoxy; benzyl; phenylthiomethyl; phenylthio; phenylthio monosubstituted in the 2-, 3- or 4-position with (C1 -C3)alkyl, pheny
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- LINEAR FREE ENERGY ORTHO-CORRELATIONS IN THE THIOPHENE SERIES.
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The acid dissociation constants of some 2-substituted thiophene-3-carboxylic acids (I: X equals OMe, Me, SMe, H, F, Cl, Br, SOMe, SO//2Me and CN) in water, at 25 degree , have been measured and correlated by means of the Yukawa-Tsuno equation ( sigma plus 1. 80, r** plus 0. 32, R 0. 996), confirming the difference, probably linked to the geometry of the five-membered ring, from the situation observed for ortho-substituted benzoic acids. The data obtained are discussed and compared with those of other substituted thiophene-carboxylic acids.
- Cosiglio,Gronowitz,Hornfeldt,Noto,Pettersson,Spinelli
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