Evolution of thiazolidine-based blockers of human Kv1.5 for the treatment of atrial arrhythmias
Blockade of the Kv1.5 ion channel is a potentially atrial-selective avenue for the treatment of atrial fibrillation and atrial flutter. The development and biological evaluation of a series of thiazolidine-based blockers of Kv1.5 is described.
Jackson, Chris M.,Blass, Benjamin,Coburn, Keith,Djandjighian, Laurent,Fadayel, Gina,Fluxe, Andrew J.,Hodson, Steven J.,Janusz, John M.,Murawsky, Michael,Ridgeway, James M.,White, Ronald E.,Wu, Shengde
p. 282 - 284
(2007/10/03)
RING-CHAIN TAUTOMERISM IN 1,3-THIAZOLIDINES
NMR spectroscopy was applied to study ring-chain tautomeric equilibria in several substituted 1,3-thiazolidines.The system highly prefers the ring form and only in the case of 2-(2'-hydroxy-5'-bromophenyl)-1,3-benzothiazoline (2d) 1H and 13C NMR spectra r
Fueloep, Ferenc,Mattinen, Jorma,Pihlaja, Kalevi
p. 6545 - 6552
(2007/10/02)
Comparative radioprotective activity of various pentagonal compounds with two heteroatomes
Various heterocyclic compounds with two heteroatomes were synthesized and their potential radioprotective activity was tested. This study shows the interest of phenylthiazolidines derivatives in chemical radioprotection.