- Pyrazolone-fused pyrimidine compound as well as preparation method and application thereof
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The invention discloses a pyrazolone-fused pyrimidine compound as well as a preparation method and application thereof. The invention provides a pyrazolone-fused pyrimidine compound as shown in a formula I which is described in the specification. The pyrazolone-fused pyrimidine compound has better inhibitory activity on WEE1 kinase.
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Paragraph 0476-0479; 0509-0512
(2021/01/11)
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- FLUORSCENT DYES WITH LARGE STOKES SHIFTS
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Herein are disclosed fluorescent dyes based around a framework for a ligand comprising a pyridyl group linked to a diaryl anilido unit. A variety of ligands based on this framework are disclosed. The ligands chelate to a BF2 center to produce the fluorescent dye. The disclosed dyes combine longer Stokes shifts (approximately 100 nm) with increased quantum yields. They are also photostable in aqueous and organic solutions for several hours. These dyes may be used in the labeling of biomolecules for bioimaging and assays. Also disclosed are methods for the synthesis of these dyes.
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- Heterocyclic compounds as inhibitors of factor VIIa
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The present invention relates generally to compounds that inhibit serine proteases. In particular it is directed to novel heterocyclic compounds, or a stereoisomer or pharmaceutically acceptable salt, solvate, or prodrug form thereof, which are useful as selective inhibitors of serine protease enzymes of the coagulation cascade; for example thrombin, factor VIIa, factor Xa, factor XIa, factor IXa, and/or plasma kallikrein. In particular, it relates to compounds that are factor VIIa inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of using the same.
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Page/Page column 40
(2008/06/13)
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- Synthesis and structure of molecular tweezers containing active site functionality
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A series of molecules has been synthesized in which a functional group is buried inside an aromatic binding cleft. These novel compounds, called "molecular tweezers", have a methyl ester (6a, 7-9a, 10a), a carboxylic acid (6b, 9b, 10b, 45), or a nitrile (
- Zimmerman, Steven C.,Zeng, Zijian,Wu, Weiming,Reichert, David E.
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p. 183 - 196
(2007/10/02)
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