1,3-Diaryl-4,5,6,7-tetrahydro-2H-isoindole derivatives: A new series of potent and selective COX-2 inhibitors in which a sulfonyl group is not a structural requisite
Novel tetrahydro-2H-isoindoles have been prepared and evaluated as inhibitors of the COX-2 isoenzyme. A 1,3-diaryl substitution on the central polycyclic ring system and absence of a sulfonyl moiety are the two structural features of this chemical series.
Portevin,Tordjman,Pastoureau,Bonnet,De Nanteuil
p. 4582 - 4593
(2007/10/03)
Dolastatin 15 derivatives
Compounds of the present invention include cell growth inhibitors which are peptides of Formula I and acid salts thereof, wherein A, D, and E are α-amino acid residues, B is an α-amino acid residue or an α-hydroxy acid residue, F is an aminobenzoic acid r
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(2008/06/13)
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