Synthesis and structure-activity relationship of C-3 substituted triazolylthiomethyl cephems
A series of C-3 substituted triazolylthiomethyl cephems with an aminothiazolemethoxyiminoacetamido side chain at C-7 were synthesized and tested for antimicrobial activity against clinically-relevant isolates. The compound with 3-pyridyl at C-5 and methyl at N-4 of the triazole moiety exhibited good antibacterial activity against both Gram-positive and Gram-negative bacteria, with the exception of pseudomonas spp against which none of the derivatives exhibited favorable activity.
Singh,Fiakpui,Galpin,Stewart,Singh,Micetich
p. 301 - 309
(2007/10/03)
FUNCTIONALIZED HYDANTOINS AS POTENTIAL ANTIBIOTICS
The 5-acylamino-3-acetylhydantoin derivatives 8 were designed as potential antibiotics mimicking lactivicin 1.The racemic compounds 19a-c, prepared in six steps from 5-oxohydantoin, were inactive onto bacterial tests.
Marchand-Brynaert, Jacqueline,Amadei, Edith,Ghosez, Leon
p. 213 - 218
(2007/10/02)
Synthesis and antibacterial activities of 2-oxaisocephems
A series of 2-oxaisocephems with a thio-substituted methyl group at the 3-position and a 2-aminothiazol-4-yl moiety at the 7-position was synthesized via benzyl 3-acetyloxymethyl-7-azido-8-oxo-1-aza-4-oxabicyclo[4.2.0]oct-2-ene-2-c arboxylate (2), derived
Tsubouchi,Tsuji,Yasumura,Ishikawa
p. 2084 - 2089
(2007/10/02)
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