Metal-Free Hydrosilylation of Ketenes with Silicon Electrophiles: Access to Fully Substituted Aldehyde-Derived Silyl Enol Ethers
Little-explored hydrosilylation of ketenes promoted by main-group catalysts is reported. The boron Lewis acid tris(pentafluorophenyl)borane accelerates the slow uncatalyzed reaction of ketenes and hydrosilanes, thereby providing a convenient access to the new class of β,β-di- and β-monoaryl-substituted aldehyde-derived silyl enol ethers. Yields are moderate to high, and Z configuration is preferred. The corresponding silyl bis-enol ethers are also available when using dihydrosilanes. The related trityl-cation-initiated hydrosilylation involving self-regeneration of silylium ions is far less effective.
Roy, Avijit,Oestreich, Martin
supporting information
p. 8273 - 8276
(2021/05/11)
An Alternative and efficient route to chlorophacinone
A straightforward synthesis for the anticoagulant rodenticide chlorophacinone is described. The short synthesis uses commercially available mandelic acid and 1,3-indanedione as staring materials.
Csuk, Rene,Barthel, Alexander,Stroehl, Dieter
experimental part
p. 95 - 97
(2011/06/09)
Affinity and selectivity at M2 and M3 muscarinic receptor subtypes of cyclic and open oxygenated analogues of 4-DAMP
Two series of cyclic (13-24) and open (25-33) phenyl substituted analogues of 1,1-dimethyl-4-diphenylacetyloxy-piperidinium iodide (4-DAMP, 1) have been synthesized and tested to evaluate their affinity and selectivity for M2 and M3