Steroidogenesis Inhibitors. 1. Adrenal Inhibitory and Interceptive Activity of Trilostane and Related Compounds
Several methylated derivatives of trilostane were prepared.Methylation of C-4 or C-4 and C-17 changes this relatively selective adrenal inhibitor to compounds with increased ovarian/placental inhibitory activity with decreased adrenal inhibitory activity.
Christiansen, Robert G.,Neumann, Helmut C.,Salvador, U. Joseph,Bell, Malcolm R.,Schane, H. Phillip,et al.
p. 928 - 931
(2007/10/02)
STEROIDAL HETEROCYCLES. VII. ANDROSTANO(2,3-D)ISOXAZOLES AND RELATED